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Mechanism of PB activation of PXR. PB can directly bind to hPXR through close interaction with the W299 residue within the ligand-binding pocket of hPXR. This interaction facilitates the recruitment of SRC-1 to the hPXR–RXR heterodimer and induces target gene expression (This figure was adopted with minor modification from Li et al., 2019, Mol. Pharmocol).
