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[Preprint]. 2023 Jul 20:2023.01.26.525697. Originally published 2023 Jan 27. [Version 2] doi: 10.1101/2023.01.26.525697

Table 1.

Overview of lipid subclass changes at 6, 9, and 12 months

6-month-old mice 9-month-old mice 12-month-old mice

Category Subclass Species
detected
ANOVA
p-val
Adj p-val
(q), N =36
Species
detected
ANOVA
p-val
Adj p-val
(q), N =24
Species
detected
ANOVA
p-val
Adj p-val
(q), N =29

Glycerophos-pholipids PC 134 0.7415 1 107 0.2928 0.3267 160 0.4243 0.4627
PE 152 0.1975 1 154 0.0284* 0.0563 119 0.5653 0.5372
PS 62 0.1171 1 58 0.0014 0.0125 25 0.46 0.4627
PI 19 0.0189 0.7144 17 0.0054 0.0168 34 0.0086* 0.0338*
MePC 17 0.9859 1 7 0.4901 0.486 15 0.7552 0.6329
PA 13 0.9596 1 6 0.7008 0.5957 9 0.0025* 0.0184*
BisMePA 4 0.1589 1 1 0.0041 0.0168 6 0.2812 0.3647
dMePE 9 0.195 1 2 0.2041 0.269 0 N/A N/A
PG 19 0.6255 1 4 0.4685 0.486 4 0.859 0.6765
BisMePE 1 0.8072 1 0 N/A N/A 0 N/A N/A
BisMePS 0 N/A N/A 0 N/A N/A 2 0.0001* 0.0022*
CL 22 0.5812 1 0 N/A N/A 0 N/A N/A
PEt 7 0.3261 1 2 0.9792 0.7283 0 N/A N/A
PMe 2 0.8695 1 0 N/A N/A 0 N/A N/A
PIP2 2 0.1393 1 0 N/A N/A 3 0.0161* 0.0394*
PIP 1 0.7034 1 0 N/A N/A 0 N/A N/A
LPC 30 0.7943 1 10 0.6835 0.5957 7 0.2805 0.3647
LPE 23 0.9947 1 16 0.6396 0.5957 4 0.0127* 0.035*
LPS 7 0.9061 1 5 0.211 0.269 2 0.0817 0.1287
LPI 7 0.7746 1 1 0.1715 0.2551 0 N/A N/A
LPG 4 0.8888 1 0 N/A N/A 0 N/A N/A
LdMePE 1 0.4552 1 0 N/A N/A 0 N/A N/A
BiotinylPE 0 N/A N/A 1 0.8078 0.6554 1 0.0225* 0.0451*

Glycerolipids TG 107 0.5998 1 44 0.0057* 0.0168* 72 0.0002* 0.0022*
MGDG 3 0.8693 1 2 0.0005 0.0089 5 0.0214* 0.0451*
MGMG 6 0.7537 1 0 N/A N/A 6 0.0497* 0.0887
DG 13 0.1381 1 70 0.1174 0.1905 59 0.6614 0.5834
SQMG 2 0.5986 1 0 N/A N/A 0 N/A N/A
SQDG 1 0.9316 1 0 N/A N/A 0 N/A N/A

Sphingolipids Hex1Cer 0 N/A N/A 85 0.0243* 0.0542 104 0.4617 0.4627
CerG1 50 0.5466 1 0 N/A N/A 0 N/A N/A
SM 47 0.6398 1 23 0.0066 0.0168 36 0.3243 0.3973
Cer 14 0.9804 1 6 0.0048 0.0168 21 0.4374 0.4627
CerP 0 N/A N/A 0 N/A N/A 17 0.0035* 0.0193*
ST 10 0.3977 1 9 0.2283 0.2717 14 0.2176 0.3199
So 3 0.4465 1 0 N/A N/A 0 N/A N/A
CerPE 0 N/A N/A 1 0.0766 0.1367 0 N/A N/A
phSM 4 0.3619 1 0 N/A N/A 0 N/A N/A
CerG2GNAc1 1 0.5784 1 0 N/A N/A 0 N/A N/A
SPH 0 N/A N/A 0 N/A N/A 1 0.775 0.6329
Hex2Cer 0 N/A N/A 0 N/A N/A 1 0.0112 0.035

Sterol Lipids ChE 1 0.5341 1 1 0.918 0.7124 2 0.9151 0.6958
ZyE 0 N/A N/A 0 N/A N/A 3 0.0092* 0.0338*

Fatty Acyls FA 2 0.5893 1 0 N/A N/A 0 N/A N/A
AcCa 0 N/A N/A 0 N/A N/A 2 0.5847 0.5372

Prenol Lipids Co 0 N/A N/A 0 N/A N/A 1 0.0523 0.0887

Total 800 632 735

Bold text indicates lipid subclasses significantly different between WT and LacQ140 mice (p<0.05 or q<0.05).

*

indicates lipid subclasses significantly different among other groups (p<0.05 or q<0.05).

One way ANOVA was conducted followed by Tukey’s multiple comparisons test, two-stage linear step-up procedure of Benjamini, Krieger, and Yekutieli, q<0.05.