. Author manuscript; available in PMC: 2023 Feb 6.

Published in final edited form as: Depress Anxiety. 2020 Mar 18;37(8):771–783. doi: 10.1002/da.23006

Table 4.

Relationship between immunomarkers, and symptoms of major depressive disorder (MDD), N=166.

Variables	OVERALL SEVERITY (IDS₃₀ TOTAL SCORE)		POSITIVE VALENCE SYMPTOMS		NEGATIVE VALENCE SYMPTOMS		OTHER MDD SYMPTOMS (IDS₂₂)
Variables	r ^a	p ^a	r ^a	p ^a	r ^a	p ^a	r ^a	p ^a
ALL SUBJECTS (n=166)
Primarily pro-inflammatory factors
Log c reactive protein (CRP)	−.030	.784	−.044	.691	−.136	.219	.020	.859
Log interferon-gamma	.226	.039	.293	.007	.046	.676	.163	.140
Log interleukin 1 beta	.002	.986	.225	.040	−.009	.937	−.097	.379
Log interleukin 2 (n=94)	−.156	.157	.102	.354	−.267	.014	−.179	.104
Log interleukin 6 (n=160)	.011	.924	.233	.033	.005	.966	−.093	.400
Log interleukin 8 (n=165)	−.108	.329	.119	.280	−.017	.879	−.197	.072
Log TNF-alpha	.052	.640	.181	.100	−.035	.749	−.001	.996
Primarily anti-inflammatory factors
Log interleukin 4	.072	.515	.224	.041	.109	.324	−.036	.743
Log interleukin 10 (n=127)	−.051	.644	.110	.321	−.040	.715	−.108	.328

MALES (n=49)
Primarily pro-inflammatory factors
Log c-reactive protein (CRP)	.050	.829	.122	.597	−.343	.128	.099	.670
Log interferon-gamma	.223	.332	.339	.133	.317	.162	.007	.975
Log interleukin 1 beta	−.123	.596	.300	.186	−.235	.305	−.258	.259
Log interleukin 2 (n=25)	−.199	.388	.270	.237	−.419	.059	−.286	.209
Log interleukin 6 (n=46)	.102	.659	.437	.047	−.054	.817	−.095	.682
Log interleukin 8	−.135	.559	.201	.383	−.408	.066	−.167	.468
Log TNF-alpha	.057	.806	.369	.100	−.238	.299	−.061	.791
Primarily anti-inflammatory factors
Log interleukin 4	−.049	.834	.193	.401	.244	.287	−.244	.286
Log interleukin 10 (n=37)	−.036	.877	.273	.232	−.232	.312	−.131	.572

FEMALES (n=117)
Primarily pro-inflammatory factors
Log c-reactive protein (CRP)	−.055	.671	−.108	.405	−.100	.441	.002	.991
Log interferon-gamma	.264	.038	.298	.019	−.046	.723	.253	.048
Log interleukin 1 beta	.053	.685	.214	.095	.044	.736	−.034	.795
Log interleukin 2 (n=69)	−.110	.394	.033	.802	−.227	.076	−.097	.454
Log interleukin 6 (n=114)	−.029	.825	.155	.228	−.008	.951	−.025	.845
Log interleukin 8 (n=116)	−.084	.516	.114	.376	.059	.647	−.186	.148
Log TNF-alpha	.067	.603	.083	.519	.010	.936	.054	.674
Primarily anti-inflammatory factors
Log interleukin 4	.168	.192	.285	.025	.057	.660	.092	.475
Log interleukin 10 (n=90)	−.036	.781	.017	.894	.029	.826	−.067	.606

Pearson’s partial correlation coefficient and controlled p = scores controlled for age.

Bold = statistically significant (p < .05) after controlling for age. CRP measured in mg/L, other immunomarkers measured in pg/ml. IDS₃₀ = Inventory of Depressive Symptomatology - Clinician Version. IDS₂₂ = IDS₃₀ excluding positive valence symptoms and negative valence symptoms items.