Table 1:

Definitions of Organ Dysfunction

Organ System	Definition of Dysfunction
Cardiovascular	On vasoactive drugs by POD 5
	or persistent lactatemia >5 mmol/L
	or hypotension < 5th percentile for age or systolic blood pressure < 2 SD below normal for age
Respiratory	Need for invasive or non-invasive ventilation by POD 5
	or persistent respiratory acidosis with PaCO2 > 65 mmHg or 20 mmHg above baseline
	or PaO2/FiO2 <300 torr in absence of cyanotic heart disease or preexisting lung disease
Renal	Cr >2 times upper limit of normal for age or 2-fold increase in baseline Cr, need for dialysis
GI/Hepatic	Total bilirubin > 4 mg/dL (outside of newborn period) or ALT 2 times upper normal limit for age, development of NEC
Hematologic	Platelet count < 80,000/mm3
	or INR > 2 in a patient not on warfarin
Neurologic	GCS < 11 in a non-sedated patient
	or acute mental status change with decrease in GCS of > 3 from baseline
	or new cerebrovascular accident

POD: post-operative day; SD: standard deviation; PaCO2: arterial partial pressure of carbon dioxide; PaO2: arterial partial pressure of oxygen; FiO2: fraction of inspired oxygen; Cr: creatinine; ALT: alanine transaminase; NEC: necrotizing enterocolitis; INR: international normalized ratio; GCS: Glascow coma score