Table 3:

Comparison of biomarker concentrations in patients with and without persistent MODS

	All	MODS	No MODS	p-value
GZMB (pg/mL)
4 hour	5.8 (2.5; 14.5)	5.5 (2.4; 20.3)	5.8 (2.6; 13.9)	0.51
12 hour	1.5 (0.3; 3.1)	2.0 (0.4; 3.3)	1.5 (0.3; 3.0)	0.28
HSP70 (pg/mL)
4 hour	44.4 (31.2; 63.4) ×104	52.8 (32.8; 75.6) ×104	43.9 (31.0; 61.6) ×104	0.93
12 hour	23.1 (14.3; 35.6) ×104	32.1 (17.8; 51.9×105)	22.6 (13.8; 32.9) ×104	0.35
IL-1 a (pg/mL)
4 hour	0.1 (0.01; 0.6)	0.01 (0.0; 0.6)	0.01 (0.0–0.6)	0.81
12 hour	0.1 (0.0; 0.6)	0.01 (0.0; 0.6)	0.01 (0.0–0.6)	0.48
IL-8 (pg/mL)
4 hour	51.5 (24.9; 97.9)	139.6 (46.1; 342.5)	45.7 (22.3; 86.8)	<0.001
12 hour	37.4 (16.5–69.2)	90.4 (40.9; 210.0)	32.7 (14.5; 55.5)	<0.001
CCL3 (pg/mL)
4 hour	23.4 (13.3; 41.9)	25.5 (13.5; 44.1)	22.9 (13.1; 41.9)	0.42
12 hour	22.5 (13.1; 22.5)	31.4 (18.2; 52.4)	21.1 (11.9; 35.0)	<0.001
CCL4 (pg/mL)
4 hour	56.5 (35.3; 84.3)	53.8 (34.5; 92.4)	56.5 (35.7; 82.7)	0.06
12 hour	35.6 (24.3; 61.0)	49.7 (24.4; 69.5)	38.2 (24.3; 58.8)	0.05
MMP-8 (pa/mL)
4 hour	1915.6 (975.7; 4307.1)	1976.6 (932.1; 5221.5)	1912.5 (1002.7; 4248.9)	0.67
12 hour	1519.1 (722.6; 3687.4)	1450.4 (717.9; 4484.2)	1526.3 (720.0; 3574.5)	0.47

Data is presented as median (interquartile range); MODS: persistent multiple organ dysfunction at postoperative day 5; GZMB, granzyme B; HSPA1B, heat shock protein 70 kDa 1B; IL-1a interleukin 1a; IL-8, interleukin 8; CCL3, C-C chemokine ligand 3; CCL4, C-C chemokine ligand 4; MMP-8, matrix metalloproteinase 8