[Preprint]. 2023 Jan 27:rs.3.rs-2468599. [Version 1] doi: 10.21203/rs.3.rs-2468599/v1

Table 2.

Frequency and percentage of HPV detection in 67 women with and without plasma AFB1-lys detection, and mean (standard deviation, or STD) and median (interquartile range, or IQR) of plasma AFB1-lys concentration (pg/uL).

HPV	HPV detection category	Plasma AFB1-lys concentration (pg/uL)			Plasma AFB1-lys detection
		N, Mean (STD)	Median (IQR)	P-Value¹³	No (N=27)	Yes (N=40)	P-Value
					n (%)	n (%)
Any HPV¹	No Detection	23, 0.030 (0.042)	0.000 (0.0000.066)	0.036	14 (51.9)	9 (22.5)	0.043¹¹
	Incident Detection	32, 0.050 (0.043)	0.052 (0.000–0.088)		10 (37.0)	22 (55.0)
	Persistent Detection	12, 0.078 (0.068)	0.081 (0.014–0.098)		3 (11.1)	9 (22.5)
HR-HPV²	No Detection	30, 0.034 (0.044)	0.000 (0.000–0.065)	0.020	17 (63.0)	13 (32.5)	0.038¹¹
	Incident Detection	26, 0.049 (0.041)	0.050 (0.000–0.091)		8 (29.6)	18 (45.0)
	Persistent Detection	11, 0.086 (0.066)	0.082 (0.027–0.098)		2 (7.4)	9 (22.5)
IARC HR-HPV³	No Detection	35, 0.046 (0.057)	0.035 (0.000–0.073)	0.410	17 (63.0)	18 (45.0)	0.361¹²
	Incident Detection	24, 0.048 (0.042)	0.046 (0.000–0.093)		8 (29.6)	16 (40.0)
	Persistent Detection	8, 0.058 (0.042)	0.078 (0.014–0.093)		2 (7.4)	6 (15.0)
A9 HPV⁴	No Detection	45, 0.045 (0.053)	0.035 (0.000–0.073)	0.395	20 (74.1)	25 (62.5)	0.567¹²
	Incident Detection	17, 0.055 (0.043)	0.067 (0.000–0.094)		5 (18.5)	12 (30.0)
	Persistent Detection	5, 0.054 (0.049)	0.082 (0.0000.089)		2 (7.4)	3 (7.5)
Non-HPV 16 A9⁵	No Detection	48, 0.044 (0.052)	0.031 (0.000–0.073)	0.171	22 (81.5)	26 (65.0)	0.175¹²
	Incident Detection	15, 0.062 (0.041)	0.079 (0.023–0.095)		3 (11.1)	12 (30.0)
	Persistent Detection	9, 0.047 (0.054)	0.045 (0.000–0.093)		2 (7.4)	2 (5.0)
A7 HPV⁶	No Detection	55, 0.048 (0.050)	0.047 (0.000–0.085)	0.097	23 (85.2)	32 (80.0)	0.236¹²
	Incident Detection	8, 0.025 (0.029)	0.016 (0.000–0.050)		4 (14.8)	4 (10.0)
	Persistent Detection	4, 0.096 (0.067)	0.086 (0.050–0.142)		0 (0.0)	4 (10.0)
Non-HPV 18 A7⁷	No Detection	59, 0.049 (0.048)	0.047 (0.000–0.085)	0.090	23 (85.2)	36 (90.0)	0.661¹²
	Incident Detection	7, 0.024 (0.031)	0.000 (0.000–0.059)		4 (14.8)	3 (7.5)
	Persistent Detection	1, 0.186 (−)	0.186 (0.186–0.186)		0 (0.0)	1 (2.5)
Vaccine-protected HR-HPV⁸	No Detection	41, 0.046 (0.054)	0.040 (0.000–0.073)	0.505	18 (66.7)	23 (57.5)	0.625¹²
	Incident Detection	18, 0.047 (0.045)	0.042 (0.000–0.094)		7 (25.9)	11 (27.5)
	Persistent Detection	8, 0.058 (0.042)	0.078 (0.014–0.093)		2 (7.4)	6 (15.0)
Vaccine-unprotected HR-HPV⁹	No Detection	47, 0.038 (0.044)	0.023 (0.000–0.079)	0.017	23 (85.2)	24 (60.0)	0.064¹²
	Incident Detection	16, 0.054 (0.040)	0.063 (0.008–0.090)		4 (14.8)	12 (30.0)
	Persistent Detection	4, 0.137 (0.071)	0.133 (0.077–0.198)		0 (0.0)	4 (10.0)
LR-HPV¹⁰	No Detection	44, 0.045 (0.047)	0.038 (0.000–0.081)	0.414	19 (70.4)	25 (62.5)	0.284¹²
	Incident Detection	22, 0.057 (0.055)	0.058 (0.000–0.091)		7 (25.9)	15 (37.5)
	Persistent Detection	1, 0.000 (−)	0.000 (0.000–0.000)		1 (3.7)	0 (0.0)

Any HPV: HPV 6, 11, 16, 18, 26, 31, 33, 35, 39, 40, 42, 45, 51, 52, 53, 54, 55, 56, 58, 59, 61, 62, 64, 66, 67, 68, 70, 71, 72, 73, 81, 82, 83, 84, CP6108, IS39

HR-HPV (High-Risk HPV): HPV 16, 18, 26, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66, 67, 68, 69, 70, 73, 82, IS39

ARC HR-HPV: HPV 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, 66

⁴

A9 HPV: HPV 16, 31, 33, 35, 52, 58

⁵

Non-HPV 16 A9: HPV 31, 33, 35, 52, 58

⁶

A7 HPV: HPV 18, 39, 45, 59, 68

⁷

Non-HPV 18 A7: HPV 39, 45, 59, 68

⁸

Vaccine-protected HR-HPV: HPV 16, 18, 31, 33, 45, 52, 58

⁹

Vaccine-unprotected HR-HPV: HPV 26, 35, 39, 51, 53, 56, 59, 66, 67, 68, 69, 70, 73, 82, IS39

¹⁰

LR-HPV (Low-Risk HPV): HPV 6, 11, 40, 42, 54, 55, 61, 62, 64, 71, 72, 81, 83, 84, CP6108

¹¹

P-value from Chi-square test

¹²

P-value from Fisher’s exact test

¹³

P-value from Wilcoxon rank sum test