Figure 4. Integrative modeling reveals molecular architecture of autoinhibited KIF5C-KLC1.
(A) The proposed model of autoinhibited KIF5C-KLC1 In cartoon diagram. (B) A model of KIF5C-KLC1(CC) via integrative modeling. The gray density is the low resolution map from negative staining EM. (C) The crosslinked pairs between KLC1-CC and KIF5C stalk, shown in the structural model. (D) The locations for the TPR domains in KIF5C-KLC1. (E) Crosslinked lysine pairs between TPR domains and KIF5C.
