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[Preprint]. 2023 Jan 27:rs.3.rs-2516002. [Version 1] doi: 10.21203/rs.3.rs-2516002/v1

Figure 4.

Figure 4

Quantification of (R)-[18F]OF-NB1 and (S)-[18F]OF-NB1 volumes of distribution (VT) across different mouse brain regions, calculated via Logan graphical analysis. A. Comparison of (R)-[18F]OF-NB1 vs. (S)-[18F]OF-NB1 retention in the whole brain, as well as in GluN2B subunitexpressing regions. B. Hippocampal volumes of distribution for (R)-[18F]OF-NB1 and (S)-[18F]OF-NB1 at baseline and following challenge with sigma2 receptor ligand, FA10 (1 mg/kg).