. Author manuscript; available in PMC: 2023 Oct 1.

Published in final edited form as: Alcohol Clin Exp Res. 2022 Sep 11;46(10):1900–1912. doi: 10.1111/acer.14932

Table 1:

Genotype groups used in ondansetron-responsive stratification for participant randomization

Ancestry/Race	Gene	Ondansetron Responsive Genotypes	Ondansetron Non-Responsive Genotypes
European Ancestry	SLC6A4	5-HTTLPR:LL	5-HTTLPR:LS/SS
		rs25531:AA	rs25531:AG/GG
		5-HTTLPR + rs25531 = L_AL_A	5-HTTLPR + rs25531 = L_GL_A; L_GL_G; L_AS; L_GS; SS
		rs1042173:TT	rs1042173:TG/GG
	HTR3A	rs1150226: AG	rs1150226: AA/GG
		rs1176713: GG	rs1176713: GA/AA
	HTR3B	rs17614942: AC	rs17614942: AA/CC

African Ancestry	SLC6A4	5-HTTLPR:LL	5-HTTLPR:LS/SS
		rs25531:AA	rs25531:AG/GG
		5-HTTLPR + rs25531 = L_AL_A	5-HTTLPR + rs25531 = L_GL_A; L_GL_G; L_AS; L_GS; SS
		rs1042173:TT	rs1042173:TG/GG
	HTR3B	rs1176744:CC/CA	rs1176744:AA

SLC6A4 – Serotonin transporter gene; HTR3A – gene encoding serotonin receptor subunit 3A; HTR3B – gene encoding serotonin receptor subunit 3B.