Extended Fig. 1. Lead 3,5-dimethyl-N-arylpyrazole TT007 specifically activates NOD2.

a-b, Activation of Null (control) and NOD1-expressing HEK-293T cells treated for 16 h with 10 μM of the indicated compound using a colorimetric assay. Activation assays were analyzed using a one-way ANOVA with Dunnett’s multiple comparisons test compared to the DMSO control. **** P < 0.0001.