Fig. 4.

Optimized S-warfarin (A) and R-warfarin (B) PBPK model with TMDD mechanism population predictions overlaid with observations in subjects with various CYP2C9 genotypes when warfarin is administered alone. Dots represent observations. Red lines represent median predictions. Gray-shaded areas represent the area between 5^th and 95^th percentiles of the model predictions. Table shows the AUC_{0–360 hours} of S- and R-warfarin by CYP2C9 genotypes. Values in table expressed as geometric means (coefficient of variations). AUC_0–360, area under the curve from time 0 to 360 hours.