TABLE 3.
Predicted S- and R-warfarin partition coefficients using method 2 (Rodgers et al.) in Simcyp version 19 (Simcyp, 2020)
| Kp Values | Sources | |
|---|---|---|
| Brain | 0.052 | Predicted |
| Gut | 0.162 | Predicted |
| Spleen | 0.101 | Predicted |
| Pancreas | 0.064 | Predicted |
| Stomach | 0.127 | Calculated as the average of nonadipose tissues |
| Liver | 0.090 | Predicted |
| Kidney | 0.134 | Predicted |
| Heart | 0.160 | Predicted |
| Lung | 0.215 | Predicted |
| Muscle | 0.038 | Predicted |
| Adipose | 0.040 | Predicted |
| Skin | 0.281 | Predicted |
| Bone | 0.103 | Predicted |
| Thymus | 0.127 | Calculated as the average of nonadipose tissues |
Kp, partition coefficient.