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. 2023 Feb;51(2):257–267. doi: 10.1124/dmd.122.001048

TABLE 5.

Fluconazole inhibitory parameters

MW (g/mol) 306.271 (PUBCHEM)
Ki (mg/L)
 4’-OH-S 8.88 (Brown et al., 2006; Damle et al., 2011)
 6-OH-S 6.74 (Brown et al., 2006)
 7-OH-S 6.74 (Brown et al., 2006)
 8-OH-S 0.64 (Damle et al., 2011)
 10-OH-S 19.3 (Brown et al., 2006; Damle et al., 2011)
 4’-OH-R 8.88 (Brown et al., 2006; Damle et al., 2011)
 6-OH-R 30.63 (Kunze et al., 1996)
 7-OH-R 12.67
 8-OH-R 0.64 (Brown et al., 2006)
 10-OH-R 19.3 (Brown et al., 2006; Damle et al., 2011)
Fluconazole effects on CLR (multiplication factor)
 S-warfarin 0.847 (Cheng et al., 2022a)
 R-warfarin 0.752 (Cheng et al., 2022a)

MW, molecular weight.