Box.

Factors Associated with Complications in Pediatric Patients with Acute Hematogenous Osteomyelitis

Factors Associated with Acute Complications [53] Fever (body temperature >100.4ºF) for more than 48 hours after starting antibiotics Bone abscess Associated suppurative arthritis Disseminated disease Delayed source control (surgical intervention more than 3 days after hospital admission)

Factors Associated with Chronic Complications [51, 53] Prolonged fever (body temperature >100.4ºF) for more than 4 days following hospital admission Disseminated disease Delayed source control (surgical intervention more than 3 days after hospital admission) Requirement for bone debridement C-reactive protein (CRP) ≥100 mg/L 2–4 days after antibiotic initiation S. aureus strain type (agr group III)

Abbreviations: agr, accessory gene regulator