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Synthetic Routes to 1A-1D. Reagents and conditions: (a) NaH (60% dispersion in mineral oil) in dry THF, 0 °C, 1 h then bis(2-pyridyloxy)methanethione, room temp., overnight, 67% (b) (8-methylimidazo[1,2-a]pyridin-2-yl)methanamine dihydrochloride, NEt3, DCM, 1 h, room temp., 96% (c) Ethanethiol or benzylthiol, NEt3, DCM, 1 h, room temp., 90–96% (d) Benzyl alcohol, NaH (60% dispersion in mineral oil), dry THF, 0 °C then 1i, room temp., 1 h, 85%.
