Fig. 4. Empirical and expected genetic correlations among psychiatric phenotypes.

(A) Ratios $(\widehat{\gamma }:={\widehat{\rho }}_{\text{xAM}}/{\widehat{\rho }}_{\text{emp}})$ of projected LD score regression (LDSC) genetic correlation estimates under xAM alone relative to empirical genetic correlation estimates (23) for six psychiatric disorders with 95% credible intervals. (B) Projected versus empirical LDSC estimates across psychiatric phenotype pairs. (C) The potential combined impacts of bidirectional errors in diagnosis and xAM on genetic correlation estimates for selected psychiatric disorder pairs. The red dashed line corresponds to $\widehat{\gamma }=1$ across all panes.