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Signaling pathways regulating virulence of the chestnut blight fungus C. parasitica; current model of the G protein signaling pathways that affect virulence and hypovirulence as a result of signal perturbation by HAV in C. parasitica. The Gα protein CPG-1 negatively regulates a putative adenylyl cyclase (AC), whereas the Gβ protein CPGB-1 and BDM-1 may function via a different pathway to regulate gene expression. HAV is hypothesized to function on G proteins or upstream targets.
