Table 2.
USP <788> Drug-Drug Combination Cumulative Results for USP Method 1 and Method 2 *
| Drug 1 | Drug 2 | USP <788> Method 1 | USP <788> Method 2 | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| LO 10+ | LO 25+ | LO Result | FI 10+ | FI 25+ | FI Result | BMI 10+ | BMI 25+ | BMI Result | ||
| Cisatracurium | Alprostadil | 11 ± 4 | 0 ± 1 | C | 38 ± 16 | 2 ± 3 | I | 5 ± 25 | 1 ± 5 | C |
| 2 mg/mL | 20 mcg/mL in D5W | |||||||||
| Cisatracurium | Ketamine | 43 ± 5 | 1 ± 1 | I | 130 ± 28 | 2 ± 3 | I | 166 ± 23 | 10 ± 8 | I |
| 2 mg/mL | 10 mg/mL | |||||||||
| Cisatracurium | Ampicillin | 11 ± 8 | 0 ± 0 | C | 101 ± 25 | 9 ± 7 | I | 95 ± 106 | 1 ± 34 | I |
| 2 mg/mL | 30 mg/mL in NS | |||||||||
| Cisatracurium | Vasopressin | 5 ± 1 | 0 ± 0 | C | 36 ± 22 | 1 ± 3 | I | 0 ± 15 | 1 ± 11 | C |
| 2 mg/mL | 1 u/mL in D5W | |||||||||
| Cisatracurium | Bumetanide | 1 ± 2 | 0 ± 1 | C | 15 ± 17 | 1 ± 2 | C | 8 ± 14 | 1 ± 16 | C |
| 2 mg/mL | 0.25 mg/mL | |||||||||
| Milrinone | Alprostadil | 4 ± 2 | 1 ± 1 | C | 72 ± 22 | 7 ± 5 | I | 13 ± 24 | 22 ± 80 | I |
| 200 mcg/mL | 20 mcg/mL in D5W | |||||||||
| Hydromorphone | Bumetanide | 2 ± 1 | 0 ± 0 | C | 36 ± 19 | 4 ± 5 | I | 30 ± 23 | 0 ± 3 | I |
| 0.5 mg/mL in D5W | 0.25 mg/mL | |||||||||
| Dexmedetomidine | Ketamine | 82 ± 6 | 0 ± 0 | I | 79 ± 20 | 4 ± 3 | I | 139 ± 25 | 12 ± 10 | I |
| 4 mcg/mL | 10 mg/mL | |||||||||
| Dexmedetomidine | Bumetanide | 4 ± 2 | 0 ± 0 | C | 38 ± 20 | 4 ± 5 | I | 1 ± 9 | 2 ± 10 | C |
| 4 mcg/mL | 0.25 mg/mL | |||||||||
| Ampicillin/sulbactam 20 mg/mL in NS | Heparin 500 u/mL in NS | 15 ± 4 | 0 ± 1 | C | 18 ± 11 | 0 ± 0 | C | 7 ± 28 | 2 ± 13 | C |
| Ampicillin/sulbactam | Bumetanide | 5 ± 1 | 0 ± 0 | C | 15 ± 9 | 0 ± 0 | C | 1 ± 19 | 1 ± 10 | C |
| 20 mg/mL in NS | 0.25 mg/mL | |||||||||
| Rocuronium | Hydromorphone | 0 ± 1 | 0 ± 0 | C | 34 ± 10 | 4 ± 5 | I | 6 ± 8 | 0 ± 4 | C |
| 10 mg/mL | 0.5 mg/mL in D5W | |||||||||
| Rocuronium | Dexmedetomidine | 2 ± 1 | 0 ± 0 | C | 48 ± 11 | 1 ± 3 | I | 0 ± 10 | 0 ± 4 | C |
| 10 mg/mL | 4 mcg/mL | |||||||||
| Rocuronium | Ketamine | 57 ± 4 | 0 ± 1 | I | 90 ± 46 | 0 ± 0 | I | 139 ± 24 | 7 ± 8 | I |
| 10 mg/mL | 10 mg/mL | |||||||||
| Rocuronium | Vasopressin | 6 ± 1 | 0 ± 0 | C | 18 ± 14 | 1 ± 2 | C | 3 ± 14 | 1 ± 10 | C |
| 10 mg/mL | 1 u/mL in D5W | |||||||||
| Rocuronium | Bumetanide | 1 ± 1 | 0 ± 0 | C | 51 ± 14 | 7 ± 7 | I | 14 ± 22 | 1 ± 7 | I |
| 10 mg/mL | 0.25 mg/mL | |||||||||
| Bumetanide | Alprostadil 20 | 4 ± 2 | 0 ± 0 | C | 14 ± 7 | 1 ± 2 | C | 5 ± 14 | 1 ± 8 | C |
| 0.25 mg/mL | mcg/ml in D5W | |||||||||
| Bumetanide | Sildenafil | 1 ± 1 | 1 ± 1 | C | 23 ± 21 | 6 ± 9 | I | 146 ± 189 | 16 ± 10 | I |
| 0.25 mg/mL | 0.8 mg/mL | |||||||||
| Bumetanide | Ampicillin | 4 ± 1 | 0 ± 1 | C | 33 ± 12 | 0 ± 0 | I | 0 ± 17 | 0 ± 5 | C |
| 0.25 mg/mL | 30 mg/mL in NS | |||||||||
| Bumetanide | Heparin | 25 ± 6 | 0 ± 0 | C | 54 ± 20 | 2 ± 3 | I | 10 ± 16 | 1 ± 8 | C |
| 0.25 mg/mL | 500 u/mL in NS | |||||||||