Table 3.
Subgroup Analysis of the Relationship Between Ln HOMA-IR and Ln OSI
| Subgroups | Subjects n (%) | Ln OSI | P-value for Interactionb | |
|---|---|---|---|---|
| β (95% CI) | P-valuea | |||
| PCOS diagnosis | < 0.0001 | |||
| PCOS | 1441 (18.39%) | −0.18 (−0.26, −0.11) | < 0.0001 | |
| Non-PCOS | 6395 (81.61%) | −0.10 (−0.13, −0.07) | < 0.0001 | |
| Tubal | 0.6371 | |||
| Tubal factor | 3961 (50.55%) | −0.12 (−0.15, −0.08) | < 0.0001 | |
| Non-tubal factor | 3875 (49.45%) | −0.13 (−0.17, −0.09) | < 0.0001 | |
| Male | 0.5504 | |||
| Male factor | 1627 (20.76%) | −0.12 (−0.17, −0.06) | < 0.0001 | |
| Non-male factor | 6209 (79.24%) | −0.12 (−0.16, −0.09) | < 0.0001 | |
| Age (y) | 0.0798 | |||
| < 35 | 6721 (85.77%) | −0.11 (−0.14, −0.08) | < 0.0001 | |
| ≥ 35 | 1115 (14.23%) | −0.11 (−0.18, −0.04) | 0.0032 | |
| BMI categories | < 0.0001 | |||
| Normal weight | 3833 (48.92%) | −0.06 (−0.10, −0.02) | 0.0028 | |
| Overweight/obese | 4003 (51.08%) | −0.23 (−0.27, −0.19) | < 0.0001 | |
| COH protocol | 0.1935 | |||
| GnRH agonist | 6526 (83.28%) | −0.11 (−0.14, −0.08) | < 0.0001 | |
| GnRH antagonist | 1310 (16.72%) | −0.15 (−0.22, −0.08) | < 0.0001 | |
Notes: aMultivariate linear regression model: adjusted for age, BMI, AMH, AFC, initial Gn dose, basal FSH, PCOS status, COH protocol, infertility type. bLog likelihood ratio test to obtain a P-value for interaction in each subgroup.
Abbreviations: OSI, ovarian sensitivity index; BMI, body weight index; PCOS, polycystic ovary syndrome; COH, controlled ovarian hyperstimulation; GnRH, gonadotropin releasing hormone; Ln, log e transformation; β, regression coefficient; CI, confidence interval.