TABLE 3.
Linear mixed model for eGFR trajectory in the first year post-transplant.
| Value | Standard error | p-value | (GVIF1/2df)2 | |
|---|---|---|---|---|
| (Intercept) | 74.82 | 9.06 | <0.001 | |
| Time (days) | 1.85 | |||
| Day 1 – day 50 | 4.22 | 2.31 | 0.067 | |
| Day 50 – day 100 | 30.90 | 3.59 | <0.001 | |
| After day 100 | 11.75 | 1.80 | <0.001 | |
| Recipient ipsilateral AIC score (per 1000 units) | 0.02 | 0.18 | 0.919 | 2.37 |
| Recipient age (per year) | −0.23 | 0.12 | 0.064 | 1.61 |
| Recipient sex | 1.36 | |||
| Male | Ref | |||
| Female | 3.52 | 2.08 | 0.094 | |
| Recipient diabetes | 1.19 | |||
| No | Ref | |||
| Yes | 0.33 | 1.93 | 0.865 | |
| Recipient smoking | 1.30 | |||
| Never | Ref | |||
| Currently | −0.04 | 2.92 | 0.988 | |
| Quit | −0.08 | 2.25 | 0.973 | |
| Previous kidney transplant | 2.22 | |||
| No | Ref | |||
| Yes | 0.43 | 3.51 | 0.902 | |
| Total dialysis duration (per month) | 0.03 | 0.06 | 0.621 | 2.54 |
| Coronary artery disease | 1.37 | |||
| None | Ref | |||
| Single vessel | 5.67 | 3.45 | 0.103 | |
| Double vessel | 5.87 | 4.58 | 0.203 | |
| Triple vessel | −2.81 | 3.75 | 0.455 | |
| Peripheral arterial disease | 1.38 | |||
| No | Ref | |||
| Yes | −4.51 | 4.41 | 0.309 | |
| Donor type | 3.24 | |||
| Living | Ref | |||
| DCD | −14.41 | 4.918 | 0.003 | |
| DBD | −7.32 | 5.016 | 0.137 | |
| Donor age (per year) | −0.29 | 0.08 | <0.001 | 1.39 |
| Donor diabetes | 1.35 | |||
| No | Ref | |||
| Yes | −6.69 | 6.06 | 0.272 | |
| Donor last creatinine (per µmol/l) | −0.04 | 0.03 | 0.150 | 1.74 |
| Pre-emptive transplant | 2.12 | |||
| Yes | Ref | |||
| No | −4.15 | 2.60 | 0.114 | |
| Cold preservation | 2.56 | |||
| Static cold storage | Ref | |||
| Hypothermic machine perfusion | 0.10 | 3.00 | 0.972 | |
| Total HLA mismatch (per 1 mismatch) | −0.21 | 0.63 | 0.744 | 1.23 |
| vPRA (per %) | −0.02 | 0.04 | 0.634 | 2.32 |
| Cold ischemic time (per minute) | 0.00 | 0.01 | 0.917 | 4.87 |
| Postoperative dialysis | 2.60 | |||
| No | Ref | |||
| Yes | −9.11 | 3.21 | 0.005 | |
| ≥1 rejection episode | 1.85 | |||
| No | Ref | |||
| Yes | −6.69 | 2.82 | 0.019 | |
| Interaction time and ipsilateral calcification | 1.96 | |||
| Day 1 – Day 50: Ipsilateral calcification score | −0.32 | 0.23 | 0.179 | |
| Day 50 – Day 100: Ipsilateral calcification score | −0.26 | 0.36 | 0.468 | |
| After Day 100: Ipsilateral calcification score | −0.47 | 0.19 | 0.014 |
ABOi, ABO incompatible; DBD, donation after brain death; DCD, donation after circulatory death; eGFR, estimated glomerular filtration rate; HLA, human leukocyte antigen; HLAi, human leukocyte antigen incompatible; vPRA, virtual panel reactive antibodies.