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. 2022 Oct 27;13(2):432–453. doi: 10.1158/2159-8290.CD-22-0528

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©2022 The Authors; Published by the American Association for Cancer Research

This open access article is distributed under the Creative Commons Attribution 4.0 International (CC BY 4.0) license.

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Figure 5. — Senescence and EC IFNγ cooperate to upregulate antigen processing and presentation machinery. A and B, mRNA expression of genes in proliferating and senescent NSP cells in vitro in the presence or absence of IFNγ (50 pg/mL) treatment. mRNA level is normalized to the mean expression of the gene in all samples. A, DEG-encoding SASP factors in our model. B, IFNγ response genes from the Hallmark signature database. C, RT-qPCR of selected antigen presentation pathway genes in proliferating and senescent cells treated with low (50 pg/mL) or high (1 ng/mL) concentration of IFNγ. Samples are from 2 biological replicates. D, MHC-I level of proliferating and senescent cells treated with IFNγ for 24 hours measured by flow cytometry. MFI, median fluorescence intensity. Data are presented as mean ± SEM.