Table 1. AP metric changes under specific ion channel block in computer simulations.
Results are reported as mean +/- standard deviation (percent change of mean from cell mean without channel block). 40,000 single cells with channel conductances varied to reflect population-level heterogeneity were paced at 0.5 Hz as described in Methods. AP metrics were determined for the penultimate beat.
| APD30 (ms) | APD50 (ms) | APD80 (ms) | APDmxr (ms) | APDtri (ms) | Rise Time (ms) | |
|---|---|---|---|---|---|---|
| No Block | 188 +/- 22 | 230 +/- 27 | 272 +/- 33 | 307 +/- 40 | 84 +/- 13 | 4.75 +/- 0.49 |
| INa Block (25% gNa, 25% gNaL) | 194 +/- 41 (+3%) | 230 +/- 45 (0%) | 273 +/- 49 (0%) | 300 +/- 94 (-2%) | 79 +/- 12 (-6%) | 8.57 +/- 2.58 (+ 80%) |
| Ito Block (25% gto) | 181 +/- 22 (-4%) | 227 +/- 27 (-1%) | 269 +/- 33 (-1%) | 305 +/- 40 (-1%) | 88 +/- 13 (+5%) | 4.87 +/- 0.44 (+ 3%) |
| ICa Block (25% pCa) | 138 +/- 21 (-27%) | 178 +/- 24 (-23%) | 223 +/- 29 (-18%) | 257 +/- 29 (-16%) | 85 +/- 11 (+1%) | 4.04 +/- 0.19 (- 15%) |
| IKr Block (25% gKr) | 287 +/- 20 (+53%) | 384 +/- 27 (+67%) | 501 +/- 38 (+84%) | 557 +/- 47 (+81%) | 214 +/- 25 (+155%) | 4.74 +/- 0.50 (-0.3%) |
| IKs Block (25% gKs) | 198 +/- 25 (+5%) | 242 +/-31 (+5%) | 285 +/- 38 (+5%) | 320 +/- 40 (+4%) | 87 +/- 14 (+4%) | 4.75 +/- 0.49 (0%) |