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. 2023 Feb 6;18(2):e0280406. doi: 10.1371/journal.pone.0280406

Table 4. Accuracy of detecting ion channel blocks from AP shape changes from computer simulation data using multi-class logistic regression.

Results are reported as mean (standard deviation). Standard deviations were obtained by repeating the model fitting, hyperparameter tuning, and testing process on different training/test dataset splits as described in Methods.

Model Overall Accuracy INa Block (TTX) IKr/INa Block (Flecainide) ICa Block (Nifedipine) IKr Block (E-4031)
Simulation Data 0.9996 (6e-5) 0.9994 (2e-4) n/a 0.9988 (3e-4) 0.9999 (5e-5)
Experimental Data 0.95 (0.03) 0.95 (0.07) 0.94 (0.08) 0.96 (0.06) 0.96 (0.07)