TABLE 6.
Examples of horizontally transferred genes in D. radiodurans
| Protein | Gene name | Taxons where homologs are found | Best BLAST hit: species, gene identifier, and e-value | Comments |
|---|---|---|---|---|
| Topoisomerase IB | DR0690 | Eucarya and double-stranded DNA viruses | Orf virus, gil521138, 2 × 10−11 | Belongs to eukaryotic type I topoisomerases; performs ATP-independent breakage of single-stranded DNA, followed by passage and rejoining; the first finding of a topoisomerase of this family in bacteria |
| Yellow protein (Drosophila) or royal jelly protein (honeybee) | DR1790 | Insecta | Drosophila subobscura, gil2222667, 1 × 10−14 | Required for cuticular pigmentation in Drosophila and important component of royal jelly of honeybee |
| Acyl coenzyme A-binding protein (ACBP) | DR0166 | Eucarya | Caenorhabditis elegans, gil2088729, 2 × 10−17 | Binds medium- and long-chain acyl coenzyme A esters with very high affinity |
| Ro RNA-binding protein | DR1262 | Eucarya | Xenopus laevis, gil1173109, 4 × 10−86 | Ribonucleoproteins complexed with several small RNA molecules; involved in UV-resistance in Deinococcus |
| LEA14-like desiccation-induced protein | DR1372 | Plantae and Archaea | Lycopersicon esculentum, gil1684830, 1 × 10−3 | Protein induced in leaves by desiccation, ethylene, or abscisic acid |
| Desiccation-induced protein | DRB0118 | Craterostigma plantagineum (plants) | Craterostigma plantagineum, gil118926, 4 × 10−19 | Protein induced in leaves by desiccation or abscisic acid |
| LEA76/LEA26-like desiccation-induced protein | DR1172 | Eucarya (mostly plants) | C. elegans, gil2353333, 2 × 10−26 | In plants, protein induced in leaves by desiccation, ethylene, or abscisic acid |
| Protein kinase of RIO1 family | DR2209 | Eucarya and Archaea | Schizosaccharomyces pombe, gil2661615, 1 × 10−12 | Protein kinase SudD, RIO1 family member, is a suppressor of bimD genes, which are involved in cell cycle control in Emericella nidulans |
| Peroxidase | DRA0145 | Polyporaceae spp. (fungi) | Polyporaceae spp., gil2160705, 4 × 10−34 | |
| Tryptophan-2,3-dioxygenase | DRA0339 | Eucarya | Drosophila simulans, gil881370, 5 × 10−18 | Converts l-tryptophan to l-formylkynurenine; binds heme; can utilize other substrates |
| l-Kynurenine hydrolase | DRA0338 | Orthologs only in Eucarya | Saccharomyces cerevisiae, gil1532216, 4 × 10−37 | Belongs to pyridoxal-dependent aminotransferase family; hydrolyzes l-kynurenine to anthranilate and l-alanine |
| Serine carboxypeptidase | DR0964 | Eucarya | Homo sapiens, >gil2098347, 9 × 10−7 | |
| Tungsten formylmethanofuran dehydrogenase, subunit E (FwdE) | DRA0267 | Archaea | Pyrococcus horikoshii, >gil3257655, 2 × 10−13 | Involved in methanogenesis; operon encoding all subunits of this enzyme contains six genes, fwdEFACDB, most of which are absent in this genome |
| Homolog of a tymocyte protein cThy28kD | DR0566 | Eucarya, Archaea, and cyanobacteria | Synechocystis spp., gil1653325, 2 × 10−28 | Bacterial proteins show significantly greater similarity to each other and to eukaryotic homologs than to archaeal homologs, which suggests horizontal transfer between bacteria and eukaryotes |
| Uncharacterized protein | DR0376 | Cyanobacteria and Aquifecales | Synechocystis spp., gil2708801, 4 × 10−44 | Probable enzymatic domain with a conserved glutamate; Synechocystis encodes at least 35 proteins of this family; Deinococcus has 3 of them |