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. 2023 Jan 6;23(1):77–88. doi: 10.17305/bjbms.2022.7677

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© 2022 Yan et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 3. — Effect of autophagy on chondrocyte metabolism in a mouse OA model. Representative pictures of IHC staining for MMP-13 (A) and Col II (B) in chondrocytes of knee tibial plateau at two and eight weeks after DMM surgery in mice, and quantitative analysis of MMP-13 (C) and Col II (D) expression. Positive cells were shown as red arrows. Scale bar: 100 µm; n = 5 per group, all data presented as means ± standard deviations. ***P < 0.001; ^###P < 0.001. OA: Osteoarthritis; IHC: Immunohistochemistry; DMM: Destabilization of the medial meniscus; MMP-13: Matrix metalloproteinase 13; Coll II: Type II collagen.