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. 2023 Jan 6;23(1):77–88. doi: 10.17305/bjbms.2022.7677

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© 2022 Yan et al.

This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

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Figure 6. — Effect of autophagy on osteoclasts and osteoblasts in subchondral bone of OA mice. TRAP staining (A) (scale bar: 200 µm) and IF staining of Runx2 (B), RANKL (C) and OPG (D) (scale bar: 100 µm) in knee subchondral bone at two and eight weeks after DMM surgery in mice. The number of mature osteoclasts (E), the expression of Runx2 (F), RANKL (G) and OPG (H), and the ratio of RANKL to OPG (I) in subchondral bone were quantitatively analyzed. Mature osteoclasts were shown as black arrows, n = 5 per group, all data presented as means ± standard deviations. *P < 0.05; ***P < 0.001; ^###P < 0.001. OA: Osteoarthritis; DMM: Destabilization of the medial meniscus; TRAP: Tartrate-resistant acid phosphatase; Runx2: Runt-related transcription factor 2; RANKL: Receptor activator for nuclear factor-κB ligand; OPG: Osteoprotegerin; IF: Immunofluorescence.