Table 3.
Comparison of characteristics between responders and non-responder in the LCQ.
| Variable | Responder† (n = 10) | Non-responder (n = 20) | P value |
|---|---|---|---|
| LCQ total | |||
| Baseline | 16.13 (13.39 to 16.86) | 17.38 (16.41 to 19.41) | .035** |
| 8 wk | 18.39 (17.07 to 19.45) | 17.26 (14.71 to 18.68) | .235** |
| Difference | 2.38 (1.79 to 3.32) | −0.51 (−1.71 to 0.13) | <.001** |
| Age, yr | 74.50 (68.00 to 77.00) | 72.50 (66.50 to 76.00) | .348*** |
| Male | 9 (90.0) | 17 (85.0) | 1.000*** |
| Weight | 69.00 (62.00 to 77.00) | 64.50 (58.50 to 70.50) | .058* |
| Height | 165.0 (162.00 to 171.00) | 160.00 (155.50 to 166.00) | .026* |
| Body mass index | 24.65 (23.84 to 28.28) | 24.75 (22.76 to 27.08) | .522* |
| Never smoker | 0 (0.0) | 4 (20.0) | .353*** |
| Ever-smokers | 10 (100.0) | 16 (80.0) | . |
| Pack-years | 40.00 (38.00 to 50.00) | 27.50 (0.00 to 42.50) | .027* |
| GAP stage | 1.00 (1.00 to 2.00) | 1.00 (1.00 to 1.50) | .100** |
| Antifibrotic agent | 10 (100.0) | 19 (95.0) | 1.000*** |
| Duration of PFD | 463.50 (281.00 to 554.00) | 439.00 (274.00 to 568.00) | .557* |
| Dyspnea, mMRC | 1.50 (1.00 to 2.00) | 1.00 (1.00 to 2.00) | .287** |
| Pulmonary function test | . | ||
| FVC, % predicted | 73.00 (67.00 to 82.00) | 84.50 (68.00 to 93.00) | .569* |
| FEV1, % predicted | 84.00 (71.00 to 95.00) | 85.00 (70.00 to 103.50) | .725** |
| DLco, % predicted | 57.50 (46.0 to 66.00) | 63.00 (53.00 to 72.00) | .318* |
| Six-minute walk test | |||
| Distance (m) | 408.00 (357.00 to 483.00) | 469.50 (354.00 to 528.00) | .435* |
| Initial SpO2 (%) | 96.00 (96.00 to 98.00) | 96.00 (94.00 to 97.00) | .234* |
| Nadir SpO2 (%) | 92.50 (91.00 to 94.00) | 92.50 (85.00 to 94.00) | .754** |
| Arterial oxygen pressure | 85.60 (66.50 to 102.10) | 87.75 (80.40 to 97.00) | .903** |
| PaCO2 (mm Hg) | 37.15 (33.25 to 41.00) | 38.05 (35.65 to 41.55) | .795* |
| WBC | 7.49 (5.45 to 7.79) | 7.35 (6.44 to 8.22) | .468** |
| IL-6 | 6.00 (3.90 to 8.80) | 5.60 (4.60 to 13.40) | .359** |
| CRP | 0.20 (0.13 to 0.29) | 0.27 (0.14 to 1.07) | .271** |
Data are presented as median (interquartile range) or number (%), unless otherwise indicated; Shapiro–Wilk’s test was employed for test of normality assumption.
CI = confidence interval, CRP = C-reactive protein, DLco = diffusing capacity of the lungs for carbon monoxide, FEV1 = forced expiratory volume in one second, FVC = forced vital capacity, GAP = gender-age-pulmonary function, IL-6 = interleukin-6, LCQ = Leicester cough questionnaire, mMRC = modified medical research council, PaCO2 = partial pressure of carbon dioxide, PFD = Pirfenidone, SpO2 = saturation of percutaneous oxygen, WBC = white blood cell.
P values were derived from independent t-test.
P values were derived from Mann-Whitney’s U test.
P values were derived from Fisher’s exact test.
Responders – patients meet criteria of minimal clinically important differences in the LCQ.