Kaplan-Meier estimates of DOR in patients with a best objective response of CR or PR. Pembrolizumab alone versus cetuximab with chemotherapy in the (A) PD-L1 CPS ≥ 20, (B) PD-L1 CPS ≥ 1, and (C) total populations at long-term follow-up and pembrolizumab with chemotherapy versus cetuximab with chemotherapy in the (D) PD-L1 CPS ≥ 20, (E) PD-L1 CPS ≥ 1, and (F) total populations. aFrom the product-limit (Kaplan-Meier) method for censored data. CPS, combined positive score; CR, complete response; DOR, duration of response; IQR, interquartile range; ORR, objective response rate; PD-L1, programmed death ligand 1; PR, partial response.