Table 2.
List of candidate genes for chromosome 3 QTL
| Gene Symbol | Gene Name | Entrez ID | Variant | Cis-eQTL Max LRS | EF (%) |
FS (%) |
Function | ||
|---|---|---|---|---|---|---|---|---|---|
| R | P | R | P | ||||||
| Gon4l | Gon-4-like (C. elegans) | 76022 | NS SNP | 82.8 | −0.607 | 0.001 | −0.619 | 0.001 | |
| Tchhl1 | Trichohyalin-like 1 | 71325 | NS SNP | 23.2 | 0.569 | 0.002 | 0.577 | 0.002 | |
| Pdzk1 | PDZ domain containing 1 | 59020 | NS SNP | 0.563 | 0.003 | 0.570 | 0.002 | ||
| Prcc | Papillary renal cell carcinoma (translocation-associated) | 94315 | NS SNP | 20 | −0.542 | 0.004 | −0.535 | 0.005 | |
| Lor | Loricrin | 16939 | NS SNP | −0.420 | 0.036 | −0.409 | 0.042 | ||
| Snapin | SNAP-associated protein | 20615 | 23.9 | −0.577 | 0.002 | −0.563 | 0.003 | IMPC | |
| Zfp697 | Zinc finger protein 697 | 242109 | 30.7 | −0.529 | 0.006 | −0.502 | 0.010 | ||
| Dap3 | Death-associated protein 3 | 65111 | 12.9 | −0.514 | 0.008 | −0.515 | 0.008 | ||
| Sprr2a1 | Small proline-rich protein 2A1 | 20755 | 22.1 | −0.418 | 0.037 | −0.411 | 0.040 | ||
| Tpm3 | Tropomyosin 3, gamma | 59069 | 0.535 | 0.005 | 0.551 | 0.004 | RGD | ||
| Wars2 | Tryptophanyl tRNA synthetase 2 (mitochondrial) | 70560 | 0.397 | 0.049 | 0.379 | 0.061 | RGD | ||
EF, ejection fraction; FS, fractional shortening; IMPC, International Mouse Phenotyping Consortium; LRS, likelihood ratio statistics; NS, nonsynonymous; RGD, rat genome database; SNP, single nucleotide polymorphism.