Table 1.
Demographics and clinical characteristics of ulcerative colitis and Crohn’s disease patients who responded to fecal urgency question in SPARC IBD
| Ulcerative colitis (n = 576) | Crohn’s disease (n = 1330) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Urgency level | ||||||||||||
| None | Mild | Moderate-severe | None | Mild | Moderate-severe | |||||||
| n | 233 | 181 | 162 | 464 | 449 | 417 | ||||||
| Demographics | n (%) unless otherwise indicated | |||||||||||
| Age, mean (± SD) | 42.3 | (14.3) | 43.4 | (15.3) | 45.3 | (15.3) | 39.7 | (13.6) | 41.7 | (14.5) | 44.1 | (14.4) |
| Gender (male) | 136 | (58.4) | 82 | (45.6) | 79 | (48.5) | 249 | (53.9) | 191 | (42.4) | 140 | (33.5) |
| Average bowel movements per day | 2.5 | (1.9) | 2.9 | (2.1) | 5.2 | (4.3) | 2.5 | (2.0) | 3.1 | (2.1) | 5.8 | (3.7) |
| Disease duration, mean (± SD) | 12.4 | (8.9) | 14 | (11.5) | 12.6 | (11.4) | 14.7 | (10.3) | 15.9 | (9.7) | 16.4 | (10.2) |
| Perianal disease | — | — | — | — | — | — | 76 | (16.5) | 68 | (15.1) | 81 | (19.4) |
| Disease involving the rectum | — | — | — | — | — | — | 123 | (26.6) | 105 | (23.4) | 111 | (26.6) |
| Stool frequency | ||||||||||||
| Normal | 189 | (81.1) | 125 | (69.1) | 42 | (25.9) | 361 | (77.8) | 285 | (63.5) | 147 | (35.3) |
| 1-2 stools > normal | 24 | (10.3) | 28 | (15.5) | 34 | (21.0) | 74 | (15.9) | 102 | (22.7) | 95 | (22.8) |
| 3-4 stools > normal | 13 | (5.6) | 17 | (9.4) | 29 | (17.9) | 19 | (4.1) | 49 | (10.9) | 75 | (18.0) |
| >4 stools > normal | 6 | (2.6) | 11 | (6.1) | 56 | (34.6) | 9 | (1.9) | 13 | (2.9) | 99 | (23.7) |
| Bleeding frequency | ||||||||||||
| None | 195 | (83.7) | 145 | (80.1) | 71 | (43.8) | 415 | (89.4) | 373 | (83.1) | 296 | (71.0) |
| Visible blood less than half of the time | 28 | (12.0) | 24 | (13.3) | 48 | (29.6) | 39 | (8.4) | 60 | (13.4) | 88 | (21.1) |
| Visible blood half of the time or more | 7 | (3.0) | 11 | (6.1) | 32 | (19.8) | 9 | (1.9) | 16 | (3.6) | 27 | (6.5) |
| Passing blood alone | 1 | (0.4) | 1 | (0.6) | 10 | (6.2) | 1 | (0.2) | - | - | 5 | (1.2) |
| Abdominal pain | ||||||||||||
| None | 182 | (78.1) | 106 | (58.6) | 48 | (29.6) | 325 | (70.0) | 227 | (50.6) | 134 | (32.1) |
| Mild | 47 | (20.2) | 57 | (31.5) | 54 | (33.3) | 111 | (23.9) | 162 | (36.1) | 161 | (38.6) |
| Moderate-severe | 4 | (1.7) | 17 | (9.4) | 60 | (37.0) | 28 | (6.0) | 60 | (13.4) | 122 | (29.3) |
| Fecal calprotectin in a subset of the cohort, n | 87 | 70 | 54 | 139 | 167 | 131 | ||||||
| < 50 μg/g | 71 | (81.6) | 46 | (65.7) | 26 | (48.2) | 115 | (82.7) | 130 | (77.8) | 93 | (71.0) |
| ≥ 50 μg/g but < 250 μg/g | 7 | (8.1) | 16 | (22.9) | 18 | (33.3) | 17 | (12.2) | 25 | (15.0) | 26 | (19.9) |
| ≥ 250 μg/g | 9 | (10.3) | 8 | (11.4) | 10 | (18.5) | 7 | (5.0) | 12 | (7.2) | 12 | (9.2) |
| Endoscopic disease activity scores in a subset of the cohort, n | 48 | 57 | 70 | 22 | 21 | 29 | ||||||
| SES_CD, mean (± SD)a | 3.3 | 3.7 | 3.6 | 6.0 | 3.6 | 4.6 | — | — | — | — | — | — |
| SES-CD, rectum, mean (± SD)a | 0.6 | 1.4 | 0.8 | 2.2 | 0.6 | 1.4 | — | — | — | — | — | — |
| Mayo score among UC, mean (± SD)a | — | — | — | — | — | — | 1.2 | 1.3 | 1.1 | 1.3 | 1.5 | 1.2 |
Abbreviations: SES-CD, simple endoscopic score for Crohn disease; UC, ulcerative colitis. Percent missing for stool frequency (<1%), bleeding frequency (<1%), and pain (<1%).
a P-values for disease activity scores: SES-CD (0.89), SES-CD rectum score (0.86), and Mayo score (0.04); values were considered significant if they were ≤ 0.05.