Figure 5.

Associations between RBD⁺ B cell and S-specific CD4⁺ T cell responses appear late in people on HD

Temporal relationships between S-specific-CD4⁺ T cells and RBD⁺ B cells in HD_S.

(A) Correlation between total CD4⁺ T cell frequencies at B–D2 and RBD⁺ B cell frequencies at D2 in HD_S (n = 20).

(B) Correlation between total CD4⁺ T cell frequencies at B–D3 and RBD⁺ B cell frequencies at D3 in HD_S (n = 20). Asterisks indicate statistically significant p values from a Spearman test (∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001). Colors indicate Spearman r.

(C) Correlations between frequencies of AIM⁺ CXCR5⁺ CD4⁺ T cells (for cT_FH) at the B–D3 visits and RBD⁺ B cell frequencies at D3 in HD_S. The r and p values from a Spearman test are indicated in each graph.