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. Author manuscript; available in PMC: 2023 Feb 7.
Published in final edited form as: Arthritis Rheumatol. 2022 Jun 20;74(8):1376–1386. doi: 10.1002/art.42138

Figure 2. Differentially expressed genes (DEGs) and their functional categories reveal transcriptomic signatures of inflammatory aortic aneurysms.

Figure 2.

(A) A total of 159 and 93 genes were identified to be significantly upregulated and downregulated, respectively, in inflammatory aortic aneurysms (Benjamini-Hochberg adjusted P-value < 0.01 and |log2(fold-change in mean expression values)| > 2). (B) Protein classes and (C) biological pathways of the upregulated DEGs. (D) Protein classes and (E) biological pathways of the downregulated DEGs. DEGs and fold-changes were calculated by DEseq2 (v1.30.0) while controlling for ACE/ARB use, statin use, history of other RD. Functional classification of protein class and biological pathways was performed using the PANTHER Database (v16.0).