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. Author manuscript; available in PMC: 2023 Feb 7.
Published in final edited form as: Arthritis Rheumatol. 2022 Jun 20;74(8):1376–1386. doi: 10.1002/art.42138

Figure 4. Transcriptomics analysis confirms higher expression of a subset of known target genes in aortitis.

Figure 4.

Among the known targets of aortitis immunosuppressive drugs (e.g., JAK inhibitors, IL6 inhibitors, Th1/Th17 inhibitors, prednisone, and methotrexate), six genes (JAK1, JAK3, IL6R, IL23A, CD80, and CD86) were found to display differential expression between inflammatory and non-inflammatory aortic aneurysms. Square and circle nodes indicate drug names and gene symbols, respectively. Edges with a hammerhead indicate inhibition. The color (blue to red) of each node represents gene expression fold-changes between inflammatory and non-inflammatory aortic aneurysms.