Table 1.
Results from previous HFpEF exercise training meta-analyses: the changes of left ventricular function and morphology, comparing exercise training vs. control groups
| Meta-analysis | Designs of included studies, n | Participants (n) (training/control) | Results of specific echocardiographic parameter meta-analysis with exercise versus control |
|---|---|---|---|
| Taylor et al. [12] |
1 –observational 1 – non-RCT 1 – RCT |
102/38 | E/e′: − 0.9, 95% CI: − 3.8 to 2.0, P = 0.53*; random effect |
|
1 –observational 1 – non-RCT 1 – RCT |
84/45 | E/A: − 0.02, 95% CI: − 0.11 to 0.06, P = 0.56*; fixed effect | |
|
1 –observational 1 – RCT |
52/24 | LV EDV (ml): 4.5, 95% CI: − 1.8 to 10.9, P = 0.16*; fixed effect | |
|
1 –observational 2 – RCT |
96/44 | LV EF (%): 0.02, 95% CI; − 1.6 to 1.7, P = 0.98*; fixed effect | |
| Pandey et al. [13] | 4 – RCT | 82/81 | E/A: 0.08, 95% CI: − 0.01 to 0.16, P = 0.08#; fixed effect |
| 3 – RCT | 62/70 | DecT (ms): 2.92, 95% CI: − 18.56 to 24.41, P = 0.79#; fixed effect | |
| 5 – RCT | 126/111 | LV EF (%): 1.26, 95% CI: − 0.13 to 2.66%, P = 0.08#; fixed effect | |
| Dieberg et al. [14] | 4 – RCT | 85/60 | E/e′: − 2.3, 95% CI: − 3.44 to − 1.19, P < 0.0001*; fixed effect |
| 3 – RCT | 56/52 | E/A: 0.07, 95% CI: 0.02 to 0.12, P = 0.005*; fixed effect | |
| 3 – RCT | 56/52 | DecT (ms): − 13.2, 95% CI: − 19.8 to − 6.5, P = 0.0001*; fixed effect | |
| Chan et al. [15] | 5 – RCT | 115/89 | E/e′: − 2.38, 95% CI: − 3.47 to − 1.28, P < 0.0001*, fixed effect |
| 4 – RCT | 86/81 | E/A: + 0.07, 95% CI: 0.02 to 0.12, P = 0.006*, fixed effect | |
| 3 – RCT | 56/52 | DecT (ms): − 13.2, 95% CI: − 19.8 to − 6.5, P = 0.0001*, fixed effect | |
| Fukuta et al. [16] | 4 – RCT | 132/109 | E/e′: − 1.20, 95% CI: − 4.07 to 1.66, P = 0.41#, random effect |
| 5 – RCT | 128/124 | E/A: 0.03, 95% CI: − 0.02 to 0.08, P = 0.27#; random effect | |
| 3 – RCT | 102/79 | e′ (cm/s): 0.49, 95% CI: − 1.28 to 2.25, P = 0.59#; random effect | |
| 3 – RCT | 62/69 | DecT (ms): − 2.04, 95% CI: − 26.53 to 22.45, P = 0.87#; random effect | |
| 4 – RCT | 140/120 | LV EDV: − 0.03, 95% CI: − 0.28 to 0.21, P = 0.78#; fixed effect | |
| 3 – RCT | 116/90 | LV mass: 0.07, 95% CI: − 0.21 to 0.35, P = 0.61#; fixed effect | |
| 7 – RCT | 202/174 | LV EF: 0.85, 95% CI: − 0.128 to 1.83, P = 0.09#; fixed effect |
*Mean difference; #weighted mean difference