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. 2023 Feb 6;14:630. doi: 10.1038/s41467-023-36399-y

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A patient with adenosquamous carcinoma of the gallbladder harbouring a HER2 amplified/S310F mutation who had progression of disease on gemcitabine plus cisplatin, FOLFOX, and FOLFIRI achieved a confirmed PR on treatment with neratinib. a Cross-sectional and treatment course imaging showing tumour response and progression (purple arrow); b serial cfDNA and c paired paired-tissue next-generation sequencing. cfDNA cell-free DNA, EOT end of treatment, FOLFIRI 5-fluorouracil/folinic acid + irinotecan, FOLFOX 5-fluorouracil/folinic acid + oxaliplatin, MSK-ACCESS Memorial Sloan Kettering-Analysis of Circulating cfDNA to Evaluate Somatic Status, MSK-IMPACT Memorial Sloan Kettering-Integrated Mutation Profiling of Actionable Cancer Targets, PR partial response, tx treatment. Source data are provided as a Source Data file.