Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2022 Nov 19;128(2):342–353. doi: 10.1038/s41416-022-02031-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — Serum samples from ovarian cancer patients were collected at timepoint 1 and up to 3 sequential treatment-related time points (e.g., for the treatment-naïve group: pre-chemo, post-chemo/pre-surgery, post-surgery/pre-chemo, and post-chemo). These were collected alongside serum samples from healthy volunteers. Serum samples were studied for sFRα and anti-FRα autoantibodies, and FRα protein expression in patient tumours and normal tissue microarrays was evaluated by immunohistochemistry. Patient characteristics, including tumour histotype, were collected from clinical databases (see Supplementary Table 1 for ovarian patients in the longitudinal study). Patient tumour burden scores were calculated from concurrent imaging (*see Supplementary Table 2 for a scoring system). N numbers are indicated in the figure.