Fig. 3. Immunohistochemical analyses reveal a mixture of cell surface and cytoplasmic FRα protein expression in ovarian cancer tissues.

a Percentage of patients with tumours expressing FRα on the membrane, in the cytoplasm, both or neither, and with membrane staining on 0–<5, 5–<25, 25–<50 or ≥50% of tumour cells. b Top left: Overall percentage of patients with each tumour histotype; Top right: Percentage of patients with membrane and cytoplasmic positivity within each histotype subgroup; Bottom left: Percentage of patients within each histotype subgroup with different proportions of membrane positive tumours cells; Bottom right: Immunohistochemical H scores calculated in each histotype subgroup.