Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Feb 6;13:2137. doi: 10.1038/s41598-023-28117-x

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

The co-transcriptome of GBS-infected human monocytes. Extensive reshaping of transcriptional activity in human monocytes containing iGBS (6 h infection) highlighting a selection of strongly activated genes with upregulated transcription (red) or downregulated transcription (green) during the host–pathogen interaction. A total of 1119 dysregulated transcripts were detected in iGBS with 745 upregulated (red) and 374 downregulated (green) transcripts (± twofold; P-adj < 0.05). Percentages of transcripts upregulated or downregulated were calculated using total numbers of mapped transcripts for GBS (2,100; using accession NZ_CP022537.1) and U937 monocytes (28,516; using accession hg38(GRCh38.p13)). These numbers for GBS were: total number of transcripts upregulated = 745/2100 (35.5%) compared to downregulated = 374/2100 (17.8%), and unchanged = 981/2100 (46.7%). The equivalent numbers for monocytes were: total number of transcripts upregulated = 547/28,516 (1.9%) compared to downregulated = 7040/28,516 (24.7%), and unchanged = 20,929/28,516 (73.4%).