Table 1.
Top transcriptional activation (upregulated) and repression (downregulated) responses of iGBS in monocytes.
| Gene locus tag | Label | Gene product | FC | P-adj |
|---|---|---|---|---|
| CHF17_RS00245 | tRNA-Ile | 232.25 | 2.17E − 11 | |
| CHF17_RS08755 | PTS beta-glucoside transporter subunit IIBCA | 198.45 | 0.00E + 00 | |
| CHF17_RS03815 | tetracycline resistance determinant leader peptide | 197.68 | 7.30E − 26 | |
| CHF17_RS00445 | adhP | Alcohol dehydrogenase AdhP | 173.27 | 0.00E + 00 |
| CHF17_RS01525 | lrgB | Antiholin-like protein LrgB | 157.58 | 1.03E − 281 |
| CHF17_RS08465 | zn-dependent alcohol dehydrogenase family protein | 104.75 | 1.19E − 254 | |
| CHF17_RS08750 | ROK family protein | 103.56 | 0.00E + 00 | |
| CHF17_RS01520 | CidA/LrgA family protein | 97.13 | 5.08E − 75 | |
| CHF17_RS02320 | 23S ribosomal RNA | 87.20 | 2.56E − 08 | |
| CHF17_RS02745 | tRNA-Ile | 66.90 | 1.32E − 05 | |
| CHF17_RS00240 | tRNA-Gly | 57.83 | 2.44E − 19 | |
| CHF17_RS00440 | adhE | Bifunctional acetaldehyde-CoA/alcohol dehydrogenase | 57.11 | 2.35E − 158 |
| CHF17_RS01970 | glpK | Glycerol kinase GlpK | 56.34 | 2.18E − 65 |
| CHF17_RS08545 | dhaS | Dihydroxyacetone kinase transcriptional activator | 51.87 | 6.33E − 229 |
| CHF17_RS04030 | ABC-2 family transporter protein | 50.06 | 0.00E + 00 | |
| CHF17_RS01980 | Aquaporin family protein | 48.84 | 1.86E − 208 | |
| CHF17_RS01975 | glpO | Type 1 glycerol-3-phosphate oxidase | 45.01 | 4.08E − 56 |
| CHF17_RS05665 | L,D-transpeptidase | 44.41 | 1.67E − 140 | |
| CHF17_RS01560 | treP | PTS system trehalose-specific EIIBC component | 38.09 | 4.87E − 250 |
| CHF17_RS05275 | CatB-related O-acetyltransferase | 34.53 | 2.24E − 180 | |
| CHF17_RS07525 | 30S ribosomal protein S21 | 33.65 | 1.37E − 64 | |
| CHF17_RS03425 | rplS | 50S ribosomal protein L19 | 32.43 | 5.52E − 281 |
| CHF17_RS04020 | HYPOTHETICAL protein | 32.07 | 0.00E + 00 | |
| CHF17_RS04025 | ABC-2 family transporter protein | 31.80 | 6.61E − 186 | |
| CHF17_RS10785 | DUF1304 domain-containing protein | 29.84 | 1.17E − 37 | |
| CHF17_RS08890 | Helix-turn-helix transcriptional regulator | − 15.17 | 3.80E − 188 | |
| CHF17_RS00770 | Helix-turn-helix transcriptional regulator | − 15.96 | 2.58E − 191 | |
| CHF17_RS01005 | 1,4-beta-N-acetylmuramidase | − 16.26 | 5.61E − 115 | |
| CHF17_RS06625 | Hypothetical protein | − 16.44 | 3.74E − 235 | |
| CHF17_RS00720 | Hypothetical protein | − 16.85 | 6.73E − 158 | |
| CHF17_RS00765 | Hypothetical protein | − 18.75 | 1.55E − 253 | |
| CHF17_RS00760 | Hypothetical protein | − 20.53 | 0.00E + 00 | |
| CHF17_RS00750 | Hypothetical protein | − 22.04 | 8.00E − 237 | |
| CHF17_RS00965 | Phage tail tape measure protein | − 22.09 | 1.80E − 171 | |
| CHF17_RS00745 | ImmA/IrrE family metallo-endopeptidase | − 25.08 | 2.11E − 251 | |
| CHF17_RS00985 | DUF1366 domain-containing protein | − 25.25 | 1.43E − 36 | |
| CHF17_RS00980 | Hypothetical protein | − 26.72 | 4.26E − 237 | |
| CHF17_RS00780 | ORF6C domain-containing protein | − 27.32 | 0.00E + 00 | |
| CHF17_RS11305 | Hypothetical protein | − 31.40 | 6.73E − 284 | |
| CHF17_RS00920 | Phage portal protein | − 41.99 | 1.29E − 248 | |
| CHF17_RS00925 | Clp protease ClpP | − 42.84 | 2.80E − 156 | |
| CHF17_RS00935 | Phage head–tail connector protein | − 45.16 | 1.39E − 107 | |
| CHF17_RS00930 | Phage major capsid protein | − 48.66 | 0.00E + 00 | |
| CHF17_RS00775 | Hypothetical protein | − 55.68 | 0.00E + 00 | |
| CHF17_RS00960 | Hypothetical protein | − 58.80 | 1.16E − 31 | |
| CHF17_RS00940 | Head–tail adaptor protein | − 66.69 | 2.28E − 69 | |
| CHF17_RS00955 | Hypothetical protein | − 100.50 | 4.67E − 172 | |
| CHF17_RS11320 | Hypothetical protein | − 129.22 | 4.41E − 63 | |
| CHF17_RS00945 | HK97 gp10 family phage protein | − 215.30 | 9.57E − 31 | |
| CHF17_RS00950 | HYPOTHETICAL protein | − 386.98 | 1.57E − 75 |