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. 2023 Feb 6;14(2):86. doi: 10.1038/s41419-023-05631-4

Fig. 8. Schematic representation of FcγRIIIA activationinducing MDSCs to alter CD4+ T cell subsets by enhancing glycolysis in Sjögren syndrome.

Fig. 8

By cross-linking with FcγRIIIA on MDSCs, immunocomplex activates the cytoplasmic ITAM, which induces the activation of mTOR to promote the expression of transcriptional factor HIF-1α. Furthermore, HIF-1α promote the expression of glycolysis-associated Glut1, HK2 and LDHA to enhance glycolysis, which results in inflammatory cytokines up-regulation leading to the decreased Th1/Th2 ratio and increased Th17/Treg ratio.