Fig. 5. Kaplan-Meier curves and multivariate analysis for distant disease-free survival according to delta increase in tumor-infiltrating lymphocytes (TIL) from baseline biopsy to residual disease.

a Kaplan–Meier curves for distant disease-free survival of TIL increase vs TIL NO increase. b Multivariate analysis for D-DFS including all variables significantly associated with D-DFS at the univariate analysis. Data were analysed by Cox regression model. TIL tumour-infiltrating lymphocytes, ypT post-neoadjuvant tumour size in centimetres, ypN post-neoadjuvant nodal status, RD residual disease, HR hazard ratio, CI confidence interval.