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. 2022 Oct 13;128(2):190–205. doi: 10.1038/s41416-022-01998-x

Fig. 5. NRF2-keap1 pathway dictates degradation or nuclear translocation of NRF2.

Fig. 5

Under normal conditions, keap1 in association with CUL3 induce proteasomal degradation of NRF2. However, under stress conditions, keap1 cysteine residues are altered, leading to NRF2 dissociation from Keap1. As a result, NRF2 translocates to the nucleus and transactivates genes involved in the suppression of lipid peroxidation and ferroptosis.