TABLE 1.

Principal members of the tetracycline class

Chemical name	Generic name	Trade name	Yr of discovery	Status	Therapeutic administration
7-Chlortetracycline	Chlortetracycline	Aureomycin	1948	Marketed	Oral
5-Hydroxytetracycline	Oxytetracycline	Terramycin	1948	Marketed	Oral and parenteral
Tetracycline	Tetracycline	Achromycin	1953	Marketed	Oral
6-Demethyl-7-chlortetracycline	Demethylchlortetracycline	Declomycin	1957	Marketed	Oral
2-N-Pyrrolidinomethyltetracycline	Rolitetracycline	Reverin	1958	Marketed	Oral
2-N-Lysinomethyltetracycline	Limecycline	Tetralysal	1961	Marketed	Oral and parenteral
N-Methylol-7-chlortetracycline	Clomocycline	Megaclor	1963	Marketed	Oral
6-Methylene-5-hydroxytetracycline	Methacycline	Rondomycin	1965	Marketed	Oral
6-Deoxy-5-hydroxytetracycline	Doxycycline	Vibramycin	1967	Marketed	Oral and parenteral
7-Dimethylamino-6-demethyl-6-deoxytetracycline	Minocycline	Minocin	1972	Marketed	Oral and parenteral
9-(t-butylglycylamido)-minocycline	Tertiary-butylglycylamidominocycline	Tigilcycline	1993	Phase II clinical trials