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. 2023 Feb 6;13:2085. doi: 10.1038/s41598-023-29242-3

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Negative association between polySia serum levels and bilateral parahippocampal gray matter volume in patients with SZ/SZA (a–c) and BD (d–f) (a) Sagittal views (x = − 20, x = 18) of the significant clusters depicting gray matter volumes correlating with polySia levels in SZ/SZA patients. (b) Scatter plot depicting the negative correlation (r = − .199, p = .025) of polySia levels and the peak voxel value (x = − 20, y = 0, z = − 32) of the cluster shown in A on the left. (c) Scatter plot depicting the negative correlation (r = − .372, p = .010) of polySia levels and the peak voxel value (x = 18, y = -42, z = −6) of the cluster shown in A on the right. (d) Sagittal views (x = -21, x = 26) of the significant clusters depicting gray matter volumes correlating with polySia levels in BD patients. (e) Scatter plot depicting the negative correlation (r = − .231, p = .004) of polySia levels and the peak voxel value (x = − 27, y = − 30, z = − 3) of the cluster shown n in (d) on ther left. (f) Scatter plot depicting the negative correlation (r = − .220, p = .013) of polySia levels and the peak voxel value (x = 26, y = − 32, z = − 2) of the cluster r shown in (d) other right. Color bars: negative correlation coefficient − r.