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. 2023 Jan 24;14:1079638. doi: 10.3389/fphys.2023.1079638

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Copyright © 2023 Dayan, Melkman-Zehavi, Reicher, Braun, Inhuber, Mabjeesh, Halevy and Uni.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dynamic expression of genes involved in gluconeogenesis (A) Fructose-1,6-bisphosphatase 1 (FBP1), regulatory enzyme, catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate (B) Glucose-6- phosphatase 2 (G6PC2), catalyzes the hydrolysis of glucose-6-phosphate, allowing the release of glucose into the bloodstream. Expression analysis of FBP1 and G6PC2 by a two-way ANOVA followed by Tukey’s HSD test revealed significant interactions between the effects of age and tissue. (p < 0.05), n = 6 per day.