TABLE 1.
Demographic Characteristics of the Different Pathologic Subgroups
| Characteristic | Pure-AD (n = 21) | AD-LB (n = 24) | Pure-LB (n = 7) |
|---|---|---|---|
| Age at death (y) | 81.8 ± 7.7 | 81.0 ± 8.4 | 88.6 ± 4.9 |
| Imaging to death (y) | 2.3 ± 3.5 | 3.3 ± 3.0 | 3.1 ± 2.7 |
| MCI (at death) | 3 | 1 | 2 |
| Dementia (at death) | 18 | 23 | 5 |
| Sex | |||
| Male | 12 | 19 | 6 |
| Female | 8 | 5 | 1 |
| APOE ɛ4 | |||
| −− | 9 | 7 | 6 |
| ± | 11 | 11 | 0 |
| ++ | 1 | 6 | 0 |
| Braak stage | |||
| I–IV | 3 | 1 | 7 |
| V | 14 | 18 | 0 |
| VI | 5 | 5 | 0 |
| LB | |||
| Limbic | 0 | 2 | 1 |
| Neocortical | 0 | 14 | 6 |
| Amygdala | 0 | 8 | 0 |
| SNnl | 0.86 ± 0.47 | 1.04 ± 0.46 | 1.57 ± 0.49 |
| 18F-FDG PET blood glucose levels (mg/dL) | 101.7 ± 11.7 | 97.8 ± 19.9 | 94.4 ± 8.2 |
| Mini-Mental State Examination score | 22.4 ± 6.6 | 21.5 ± 5.7 | 24.7 ± 3.9 |
| MEM | −1.06 ± 0.94 | −1.61 ± 0.66 | −0.69 ± 0.67 |
| EXEC | −1.36 ± 1.21 | −1.48 ± 0.95 | −1.50 ± 0.95 |
| Δ (MEM − EXEC) | 0.16 ± 0.50 | −0.33 ± 0.71 | 0.53 ± 0.55 |