eTable 3. Data sources and methodologies (morbidity component).
| Cause of burden of disease | Regional divisions* | Excluded age groups | Components | Data source | Year | Reference | Unit | Methodology |
| Lower respiratory infections | D, FS, SPR | none | Incidence | AOK claims data | 2017 | (19, 20) | Rate (cases per 100 000 person-years) | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | GBD study | 2017 | (27, e5) | Relative proportion of case rate | ||||
| Duration | GBD study | 2017 | (27, e5) | Days per year | ||||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Tracheal, bronchial and lung cancer | D, FS, SPR | <25 years (data limitation) | Prevalence | AOK claims data | 2017 | (19, 20) | 10-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data | 2017 | (19, 20) | Relative proportion of 10-year prevalence | Age and sex stratification | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Breast cancer | D, FS, SPR | <20 years (data limitation) | Prevalence | AOK claims data | 2017 | (19, 20) | 10-year-prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data | 2017 | (19, 20) | Relative proportion of 10-year prevalence | Age stratification (females only) | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Prostate cancer | D, FS, SPR | <40 years (data limitation) | Prevalence | AOK claims data | 2017 | (19, 20) | 10-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data | 2017 | (19, 20) | Relative proportion of 10-year prevalence | Age stratification (males only) | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Colorectal cancer | D, FS, SPR | <20 years (data limitation) | Prevalence | AOK claims data | 2017 | (19, 20) | 10-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data | 2017 | (19, 20) | Relative proportion of 10-year prevalence | Age and sex stratification | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Coronary heart disease | D, FS, SPR | Myocardial infarction <25 years, angina pectoris none, heart failure <25 years (expert opinion) | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence; rate (cases per 100 000 person years) | Age, sex and morbidity-adjusted extrapolation (21); rate corresponds to myocardial infarctions as proportion of heart disease |
| Severity distribution | AOK claims data; GBD study | 2017 | (19, 20, 27) | Relative proportion of 1-year prevalence or 1-year rate | Age and sex stratification (heart failure and myocardial infarction); angina pectoris taken from GBD study | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Stroke | D, FS, SPR | none | Prevalence | AOK claims data | 2017 | (19, 20) | 10-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | GBD study | 2017 | (27, e6) | Relative proportion of 10-year prevalence | ||||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Hypertensive heart disease | D, FS, SPR | <25 years (expert opinion) | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data | 2017 | (19, 20) | Relative proportion of 1-year prevalence | Age and sex stratification | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Chronic obstructive lung disease | D, FS, SPR | <35 years (expert opinion) | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | GBD study | 2013 | (27, e7) | Relative proportion of 1-year prevalence | ||||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Alzheimer’s disease and other dementia | D, FS, SPR | <40 years (expert opinion) | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | GBD study | 2017 | (27, e6) | Relative proportion of 1-year prevalence | ||||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Alcohol use disorders | D | <18 and >64 years (survey-related restriction) | Prevalence | Epidemiological survey of substance abuse | 2018 | (25) | 1-year prevalence | Extrapolation considering sampling approach |
| Severity distribution | GBD study | 2017 | (27, e6) | Relative proportion of 1-year prevalence | ||||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Anxiety disorders | D, FS, SPR | none | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | GBD study | 2017 | (27, e6) | Relative proportion of 1-year prevalence | ||||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Depressive disorders | D, FS, SPR | Major depression and dysthymia < 15 years (expert opinion) | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data, GBD study | 2017 | (19, 20, 27) | Relative proportion of 1-year prevalence | Age and sex stratification (major depression: AOK claims data; dysthymia: GBD study) | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Duration | RKI study data | 2009–2012 | (36) | Days per year | Extrapolation considering sampling approach (major depression) | |||
| Diabetes mellitus | D, FS, SPR | Type 1 diabetes none, Type 2 diabetes <10 years (expert opinion) | Prevalence | AOK claims data | 2017 | (19, 20) | 1-year prevalence | Age, sex and morbidity-adjusted extrapolation (21) |
| Severity distribution | AOK claims data | 2017 | (19, 20) | Relative proportion of 1-year prevalence | Age and sex stratification | |||
| Disability weight | GBD study | 2017 | (27, e8, e9) | Weight | ||||
| Low back pain | D | <18 years (restriction due to telephone survey) | Prevalence | RKI survey data | 2019/2020 | (23) | 1-year prevalence | Extrapolation considering sampling approach |
| Severity distribution | RKI survey data | 2019/2020 | (23) | Relative proportion of 1-year prevalence | Extrapolation considering sampling approach | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Duration | RKI survey data | 2019/2020 | (23) | Days per year | Extrapolation considering sampling approach | |||
| Neck pain | D | <18 years (restriction due to telephone survey) | Prevalence | RKI survey data | 2019/2020 | (23) | 1-year prevalence | Extrapolation considering sampling approach |
| Severity distribution | RKI survey data | 2019/2020 | (23) | Relative proportion of 1-year prevalence | Extrapolation considering sampling approach | |||
| Disability weight | GBD study | 2017 | (27) | Weight | ||||
| Duration | RKI survey data | 2019/2020 | (23) | Days per year | Extrapolation considering sampling approach | |||
| Road injuries | D, FS, SPR | none | Prevalence | Road injury statistics | 2017 | (26, e10, e11) | 1-year prevalence | Number of transport injuries corrected for the proportion of accidents not recorded by the police by using survey data (see [13] for details) |
| Severity distribution | GBD study | 2017 | (27) | Relative proportion of 1-year prevalence | Proportion of injuries (or groups of injuries) within the respective road traffic accident; use of the Global Burden of Disease results (see [13] for details) | |||
| Disability weight | GBD study | 2017 | (27) | Weight | Use of average disability weights (see [13] for details) | |||
| Headache disorders | D | <18 years (restriction due to telephone survey) | Prevalence | RKI survey data | 2019/2020 | (24) | 1-year prevalence | Extrapolation considering sampling approach |
| Severity distribution | RKI survey data | 2019/2020 | (24) | Proportion of days per year with symptoms of all days of the year | Extrapolation considering sampling approach | |||
| Disability weight | GBD study | 2017 | (27) | Weight |
* D, Germany; FS, federal states; SPR, spatial planning regions