eTable 5. Total burden of disease (DALY per 100 000 population [pop]) of the selected causes of burden of disease with increasing age and according to sex (level 3, Germany).

a) Females
	20–24	25–29	30–34	35–39	40–44	45–49	50–54	55–59	60–64	65–69	70–74	75–79	80–84	85–89	90–94	95 +
Lower respiratory infections	35	29	28	25	23	37	71	126	190	223	392	612	1097	1890	2849	3593
COPD				101	167	308	583	1038	1677	2089	2574	2533	2917	3290	3460	3236
Lung cancer		8	19	73	224	513	887	1716	2344	2591	2547	1786	1309	938	599	330
Breast cancer	3	92	339	615	877	1194	1477	1670	1877	2261	2439	2420	2489	2246	2149	2030
Prostate cancer
Bowel cancer	6	33	53	110	186	311	447	573	751	1000	1284	1513	1836	2188	2368	2036
IHD		37	43	99	172	316	490	765	1307	2048	3127	4813	8412	13 646	19 320	23 749
Stroke	36	62	78	121	179	309	353	501	635	977	1625	2635	4390	6471	8342	8829
Hypertensive heart disease			1	2	4	20	44	84	171	257	507	1009	2168	4245	7200	10 911
Diabetes	34	54	81	126	202	326	492	721	1107	1558	2109	2793	3922	4682	4868	4485
Dementias					16	19	48	107	212	458	1177	2508	5518	9963	14 523	18 509
Depressive disorders	344	417	521	662	847	901	1035	1107	1192	1229	1186	1283	1346	1258	1231	1204
Anxiety disorders	520	618	716	798	879	968	1098	1123	1089	1087	1037	964	895	779	670	571
Alcohol use disorders	546	418	270	143	223	195	379	292	395	170	116	81	49	29	25	7
Low back pain	1371	1676	1618	1728	1720	2574	2444	2196	2333	2850	3067	2740	1924	1893	1764	1649
Headache disorders	2075	2646	2580	2025	1932	1961	1517	1316	982	612	455	355	289	266	265	226
Neck pain	483	544	899	801	887	1156	1135	994	930	1171	967	1 064	859	722	597	473
Road injuries	415	204	157	112	94	130	150	148	118	103	137	128	129	91	43	18
b) Males
	20–24	25–29	30–34	35–39	40–44	45–49	50–54	55–59	60–64	65–69	70–74	75–79	80–84	85–89	90–94	95 +
Lower respiratory infections	24	17	33	46	43	97	136	206	343	508	796	1117	1922	3115	4594	6186
COPD				97	192	363	730	1360	2198	3104	3974	4201	4750	5562	5976	5181
Lung cancer		2	19	113	276	662	1412	2840	4182	4993	5365	4556	3704	2942	2145	1131
Breast cancer
Prostate cancer					1	17	143	355	862	1486	2386	3462	4191	5379	5782	5409
Bowel cancer	2	15	124	114	207	359	629	1012	1487	1958	2330	2538	2804	2995	3103	2608
IHD		49	140	345	794	1381	2194	3515	4964	6575	8014	10 559	15 125	21 257	26 700	30 304
Stroke	26	19	65	125	177	345	506	816	1249	1853	2702	3718	5297	6934	8156	8163
Hypertensive heart disease		1	2	5	46	58	107	168	322	494	692	1087	1969	3329	5124	6613
Diabetes	31	49	88	133	299	500	841	1242	1919	2568	3157	3732	4595	4998	4870	4221
Dementias					17	22	51	110	289	590	1382	2817	5564	9564	12 776	14 649
Depressive disorders	161	197	243	315	393	417	494	555	585	563	550	571	593	586	594	594
Anxiety disorders	295	328	382	409	465	507	537	567	560	520	481	452	431	423	409	379
Alcohol use disorders	1334	1038	1068	897	940	1036	1106	1090	961	640	369	261	197	83	26	2
Low back pain	1421	1673	1650	1788	1788	2322	2195	1970	2095	2421	2629	2287	1549	1541	1468	1439
Headache disorders	1181	1338	1531	1116	1138	1079	882	673	689	504	391	321	292	288	298	256
Neck pain	222	261	301	255	295	676	657	546	500	633	497	558	433	409	350	296
Road injuries	855	638	467	401	340	347	343	300	255	214	185	208	187	177	95	44
		Legende		<1340		1340 <3900		3900 <9000		9000 <17 000			≥17 000

Source: BURDEN 2020; YLL: Cause of death statistics 2017 (31), Federal Statistical Office of Germany 2018 (32); YLD: eTable 3; own calculations; due to data limitations, a comparison of the causes of burden of disease is only presented from the age group of 20 year-olds onwards (etable 3); both grouping and the resulting color scheme were created using the natural breaks method (33); COPD, chronic obstructive pulmonary disease; DALY, disability-adjusted life years; IHD, ischemic heart disease