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. 2023 Jan 24;14:1084283. doi: 10.3389/fimmu.2023.1084283

Figure 5.

Figure 5

Schematic picture of platelet as a source of autoantigens and persistent inflammation in RA. Autoantibodies ACPA recognized citrullinated proteins in platelet, result in platelet activation, aggregation, and microparticles releasing. This will further lead to citrullinated proteins exposure to the immune cell, triggering of ACPA production and contribute to the persistent inflammation.