Table 1.
Association of SLE clinical manifestations with miR-146a and pro-inflammatory cytokines in SLE patients.
| Measured parameter | miR-146a (M±SE) | IL-1β (M±SE) | IL-6 (M±SE) | IL-17 (M±SE) | IL-8 (M±SE) | TNF-α (M±SE) |
|---|---|---|---|---|---|---|
| Mucocutaneous manifestation | ||||||
| Yes [93 (83%)] | 1.92 ± 0.20 | 19.83 ± 1.86**/** | 14.12 ± 1.14 | 982.44 ± 213.46 | 76.76 ± 12.51 | 20.68 ± 2.63 |
| No [20 (17%)] | 1.91 ± 0.37 | 29.41 ± 3.24 | 17.73 ± 2.88 | 1494.28 ± 710.99 | 82.44 ± 38.72 | 29.66 ± 5.31 |
| Malar rash | ||||||
| Yes [82 (73%)] | 1.99 ± 0.23 | 19.78 ± 2.10 | 14.51 ± 1.26 | 1104.48 ± 251.44 | 92.55 ± 16.08 | 18.37 ± 2.32*/* |
| No [31 (27%)] | 1.73 ± 0.21 | 24.89 ± 2.69 | 15.36 ± 2.07 | 966.26 ± 394.49 | 41.03 ± 12.02 | 31.47 ± 5.57 |
| Photosensitivity | ||||||
| Yes [60 (54%)] | 2.61 ± 0.21*/* | 19.18 ± 2.11 | 14.56 ± 1.55 | 980.57 ± 248.84 | 91.49 ± 19.01 | 16.91 ± 1.89*/* |
| No [53 (46%)] | 1.81 ± 0.25 | 23.45 ± 2.57 | 14.97 ± 1.49 | 1169.09 ± 393.45 | 62.78 ± 14.62 | 28.11 ± 4.43 |
| Oral ulcers | ||||||
| Yes [57 (51%)] | 1.91 ± 0.25 | 21.97 ± 2.12 | 14.46 ± 1.27 | 1077.36 ± 232.09 | 29.38 ± 3.60 | 21.60 ± 3.21 |
| No [56 (49%)] | 1.98 ± 0.25 | 27.48 ± 3.33 | 15.61 ± 2.03 | 1074.31 ± 437.60 | 28.21 ± 1.86 | 23.33 ± 3.43 |
| Alopecia | ||||||
| Yes [34 (30%)] | 1.73 ± 0.20*/NS | 20.51 ± 1.96 | 13.44 ± 1.85 | 585.21 ± 195.09 | 36.47 ± 6.65*/* | 24.11 ± 3.52 |
| No [79 (70%)] | 2.06 ± 0.25 | 25.87 ± 2.53 | 15.44 ± 1.32 | 1370.91 ± 312.96 | 25.42 ± 1.18 | 21.39 ± 3.09 |
| Serositis | ||||||
| Yes [45 (40%)] | 1.95 ± 0.28 | 20.41 ± 2.11 | 16.64 ± 1.90 | 560.98 ± 249.92 | 77.66 ± 18.52 | 21.39 ± 2.80 |
| No [68 (60%)] | 1.90 ± 0.23 | 22.01 ± 2.41 | 13.47 ± 1.24 | 1378.97 ± 294.61 | 77.70 ± 16.04 | 22.72 ± 3.49 |
| Vasculitis | ||||||
| Yes [30 (26%)] | 2.50 ± 0.22**/* | 27.20 ± 3.95*/* | 15.90 ± 1.97 | 2066.03 ± 516.50 | 85.75 ± 27.58 | 26.58 ± 5.33 |
| No [83 (74%)] | 1.70 ± 0.17 | 18.97 ± 1.66 | 14.32 ± 1.28 | 965.61 ± 214.93 | 74.72 ± 13.96 | 20.48 ± 2.57 |
| Raynaud’s phenomena | ||||||
| Yes [20 (17%)] | 2.71 ± 0.12**/* | 28.07 ± 5.32*/NS | 16.40 ± 2.30 | 633.89 ± 502.11 | 89.02 ± 31.73 | 24.11 ± 5.48 |
| No [93 (83%)] | 1.90 ± 0.16 | 19.69 ± 1.58 | 14.38 ± 1.21 | 1154.61 ± 231.89 | 75.15 ± 13.13 | 21.74 ± 2.65 |
| Neuropsychiatric disorders | ||||||
| Yes [14 (12%)] | 2.65 ± 0.11**/* | 22.83 ± 3.56 | 25.51 ± 3.24***/** | 765.27 ± 549.81 | 47.22 ± 19.79 | 28.75 ± 5.02 |
| No [99 (88%)] | 1.80 ± 0.13 | 21.12 ± 1.88 | 13.12 ± 1.02 | 1119.13 ± 229.15 | 83.22 ± 13.84 | 21.17 ± 2.63 |
| Pancytopenia | ||||||
| Yes [26 (23%)] | 2.21 ± 0.12*/NS | 24.87 ± 3.88 | 15.47 ± 2.51 | 1512.25 ± 539.10 | 75.20 ± 22.11 | 21.90 ± 3.80 |
| No [87 (77%)] | 1.82± 0.19 | 20.26 ± 1.83 | 14.60 ± 2.51 | 917.07 ± 216.37 | 78.47 ± 14.44 | 22.26 ± 2.79 |
| Thrombocytopenia | ||||||
| Yes [27 (24%)] | 2.56 ± 0.10*/NS | 22.33 ± 3.16 | 14.01 ± 1.74 | 1263.14 ± 374.87 | 34.13 ± 6.57 | 19.87 ± 2.64 |
| No [86 (76%)] | 1.80 ± 0.22 | 25.30 ± 2.27 | 15.07 ± 1.34 | 937.62 ± 250.76 | 26.35 ± 1.12 | 23.21 ± 3.22 |
| Hemolytic anemia | ||||||
| Yes [17 (15%)] | 2.80 ± 0.20*/* | 25.54 ± 3.93 | 17.14 ± 2.61 | 1658.46 ± 681.29 | 33.19 ± 3.80 | 31.39 ± 8.86 |
| No [96 (85%)] | 1.86 ± 0.18 | 24.03 ± 2.09 | 14.32 ± 1.17 | 920.93 ± 202.99 | 27.93 ± 2.64 | 20.48 ± 2.27 |
| Leucopenia | ||||||
| Yes [34 (30%)] | 2.46 ± 0.13*/* | 26.77 ± 3.01 | 15.99 ± 1.78 | 1501.54 ± 416.28 | 36.07 ± 6.17*/NS | 25.85 ± 4.16 |
| No [79 (70%)] | 1.74 ± 0.21 | 22.93 ± 2.03 | 14.70 ± 1.14 | 1137.69 ± 233.41 | 26.42 ± 1.26 | 21.94 ± 2.64 |
| Neutropenia | ||||||
| Yes [18 (16%)] | 2.59 ± 0.12*/* | 32.40 ± 4.23 | 16.22 ± 3.43 | 761.59 ± 548.78 | 44.91 ± 14.79**/* | 25.32 ± 4.83 |
| No [95 (84%)] | 1.80 ± 0.20 | 22.93 ± 2.03 | 14.70 ± 1.14 | 1137.69 ± 233.43 | 26.42 ± 1.26 | 21.94 ± 1.64 |
| Lymphopenia | ||||||
| Yes [35 (31%)] | 2.48 ± 0.13*/* | 27.59 ± 3.12 | 15.50 ± 1.91 | 1290.37 ± 370.97 | 36.03 ± 6.19*/* | 26.80 ± 4.24 |
| No [78 (69%)] | 1.75 ± 0.20 | 22.13 ± 2.38 | 14.61 ± 1.35 | 924.41 ± 252.80 | 25.11 ± 1.25 | 20.38 ± 2.99 |
| Arthritis | ||||||
| Yes [63 (56%)] | 1.95 ± 0.27 | 21.89 ± 2.75 | 13.55 ± 1.34 | 972.95 ± 316.69 | 104.89 ± 19.95*/* | 22.70 ± 3.85 |
| No [50 (44%)] | 1.89 ± 0.24 | 21.08 ± 2.21 | 14.96 ± 1.71 | 1204.35 ± 301.79 | 45.49 ± 10.42 | 21.95 ± 3.03 |
| Renal disorders | ||||||
| Yes [53 (47%)] | 1.97 ± 0.22 | 20.19 ± 2.01 | 13.77 ± 1.33 | 1225.16 ± 265.60 | 71.17 ± 15.69 | 21.67 ± 2.81 |
| No [60 (53%)] | 1.80 ± 0.30 | 22.98 ± 2.95 | 16.86 ± 1.82 | 753.92 ± 274.51 | 87.56 ± 16.69 | 23.53 ± 4.51 |
| Anti-dsDNA Ab | ||||||
| Yes [113 (100%)] | 1.93 ± 0.20 | 24.31 ± 2.17 | 13.98 ± 1.24 | 1123.87 ± 254.53 | 59.54 ± 12.86**/** | 26.26 ± 3.10*/NS |
| No [0 (0%)] | 1.76 ± 0.44 | 28.86 ± 5.84 | 16.36 ± 4.28 | 784.97 ± 420.64 | 147.45 ± 32.49 | 13.22 ± 2.50 |
PC: P corrected; *: p < 0.05; **: p < 0.01; ACR: American College of Rheumatology; M: Mean; SE: Standard Error; Anti-dsDNA; Ab; Anti-double-stranded DNA.